biostudies-literatureLinder SMClinicalTrials.govEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNICHD NIH HHS591-601https://www.ebi.ac.uk/biostudies/studies/S-EPMC12324965biostudies-literatureUnknown39(8)<h4>Background</h4>Physical, cognitive, and psychosocial impairments experienced by individuals post-stroke detrimentally impact health-related quality of life (HRQoL). Rehabilitation interventions targeting the recovery of motor function aim to improve community reintegration and HRQoL. Aerobic exercise has also been shown to have global effects in individuals post-stroke, positively affecting motor and mood-related outcomes.<h4>Objective</h4>To determine the effects of forced-rate aerobic exercise (FE) coupled with upper extremity repetitive task practice (RTP) on HRQoL and mood in individuals post-stroke.<h4>Methods</h4>A rater blinded randomized clinical trial was conducted. Individuals ≥6 months post-stroke received 90-minute sessions of FE+RTP or time-matched RTP alone, 3×/week for 8Neurorehabilitation and neural repairTask Practice With and Without Aerobic Exercise Improves Health-related Quality of Life and Social Participation Post-stroke: A Randomized Clinical Trial.PMC12324965K01 HD092556NCT03819764K01HD092556Li YAlberts JLBischof-Bockbrader AHarris DDavidson SLinder SMBethoux FLapin BInce Hocaoglu OEfalseTask Practice With and Without Aerobic Exercise Improves Health-related Quality of Life and Social Participation Post-stroke: A Randomized Clinical Trial.<h4>Background</h4>Physical, cognitive, and psychosocial impairments experienced by individuals post-stroke detrimentally impact health-related quality of life (HRQoL). Rehabilitation interventions targeting the recovery of motor function aim to improve community reintegration and HRQoL. Aerobic exercise has also been shown to have global effects in individuals post-stroke, positively affecting motor and mood-related outcomes.<h4>Objective</h4>To determine the effects of forced-rate aerobic exercise (FE) coupled with upper extremity repetitive task practice (RTP) on HRQoL and mood in individuals post-stroke.<h4>Methods</h4>A rater blinded randomized clinical trial was conducted. Individuals ≥6 months post-stroke received 90-minute sessions of FE+RTP or time-matched RTP alone, 3×/week for 82025-01-01T00:00:00Z2025 Aug2026-04-12T15:14:30.895Z2026-04-07T13:17:44.491ZS-EPMC123249654040178410.1177/15459683251338784