biostudies-literatureOuyang HHong Kong Polytechnic UniversityResearch Grants Council108https://www.ebi.ac.uk/biostudies/studies/S-EPMC12325440biostudies-literatureUnknown20(1)Post-stroke fracture risk necessitates investigation of bone properties and contributing factors. The decline in paretic tibia failure load post-stroke was attributed to decreased trabecular bone density and thickness at 2-year follow-up. Less decline in bone strength was associated with better leg blood flow, walking speed, strength, and activity at baseline.<h4>Purpose</h4>To delineate long-term changes in distal tibia bone properties after stroke and identify their associated factors.<h4>Methods</h4>High-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the bilateral distal tibia were performed in 46 chronic stroke participants (age, 60.4 ± 7.8 years; post-stroke onset, 6.3 ± 4.2 years) and 45 controls (age, 57.7 ± 6.3 years) at baseline and 2 years later. We meaArchives of osteoporosisLongitudinal bone loss in the paretic leg and its contributing factors in individuals with chronic stroke: a 2-year prospective cohort study.PMC12325440PhD studentshipGeneral Research Fund: 151031/18MHung VWYYing MTCQin LOuyang HMiller TLeung TWHPang MYCfalseLongitudinal bone loss in the paretic leg and its contributing factors in individuals with chronic stroke: a 2-year prospective cohort study.Post-stroke fracture risk necessitates investigation of bone properties and contributing factors. The decline in paretic tibia failure load post-stroke was attributed to decreased trabecular bone density and thickness at 2-year follow-up. Less decline in bone strength was associated with better leg blood flow, walking speed, strength, and activity at baseline.<h4>Purpose</h4>To delineate long-term changes in distal tibia bone properties after stroke and identify their associated factors.<h4>Methods</h4>High-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the bilateral distal tibia were performed in 46 chronic stroke participants (age, 60.4 ± 7.8 years; post-stroke onset, 6.3 ± 4.2 years) and 45 controls (age, 57.7 ± 6.3 years) at baseline and 2 years later. We mea2025-01-01T00:00:00Z2025 Aug2026-03-31T11:59:06.771Z2025-09-01T03:08:27.5ZS-EPMC123254404076445610.1007/s11657-025-01541-4