{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Han B"],"funding":["Clinical Research Incubation Program, Beijing Chaoyang Hospital, Capital Medical University"],"pagination":["273"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12326817"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(1)"],"pubmed_abstract":["<h4>Background</h4>Postoperative surgical site infections (SSIs) following adult scoliosis deformity (ASD) correction surgery are receiving more attention globally. Intrawound vancomycin powder in spinal surgical wounds has emerged as a promising strategy to prevent SSIs in recent years. However, the efficacy and safety of intrawound vancomycin powder in preventing SSIs following ASD correction surgery are still very controversial. This protocol describes a prospective, randomized controlled, multicenter clinical trial aimed at verifying vancomycin's efficacy and safety.<h4>Methods</h4>This is a study protocol for multicenter randomized controlled trial on efficacy and safety of intrawound vancomycin powder in preventing SSIs after ASD correction surgery. Eligible ASD patients (n = 264) wi"],"journal":["Trials"],"pubmed_title":["The efficacy and safety of intrawound vancomycin powder to prevent surgical site infection in adult scoliosis surgery (Vanco-SSIASS): study protocol for a prospective, randomized controlled, assessor‑blinded, open‑label, multicenter trial."],"pmcid":["PMC12326817"],"funding_grant_id":["Key Project CYFH202322"],"pubmed_authors":["Chu S","Han B","Yang Y","Li Z","Liang W","Sun D","Yin P","Guo T","Hai Y","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"The efficacy and safety of intrawound vancomycin powder to prevent surgical site infection in adult scoliosis surgery (Vanco-SSIASS): study protocol for a prospective, randomized controlled, assessor‑blinded, open‑label, multicenter trial.","description":"<h4>Background</h4>Postoperative surgical site infections (SSIs) following adult scoliosis deformity (ASD) correction surgery are receiving more attention globally. Intrawound vancomycin powder in spinal surgical wounds has emerged as a promising strategy to prevent SSIs in recent years. However, the efficacy and safety of intrawound vancomycin powder in preventing SSIs following ASD correction surgery are still very controversial. This protocol describes a prospective, randomized controlled, multicenter clinical trial aimed at verifying vancomycin's efficacy and safety.<h4>Methods</h4>This is a study protocol for multicenter randomized controlled trial on efficacy and safety of intrawound vancomycin powder in preventing SSIs after ASD correction surgery. Eligible ASD patients (n = 264) wi","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-03-31T12:16:26.738Z","creation":"2025-09-01T03:08:36.117Z"},"accession":"S-EPMC12326817","cross_references":{"pubmed":["40764586"],"doi":["10.1186/s13063-025-09000-8"]}}