{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang C"],"funding":["Shanghai Science and Technology Innovation Action Plan","Natural Science Foundation of Shanghai","Natural Science Foundation of Shanghai Municipality","National Natural Science Foundation of China","Shanghai Clinical Research Center for Gynecological Diseases"],"pagination":["747-773"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12328091"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(7)"],"pubmed_abstract":["<h4>Background</h4>Tumor-associated neutrophils (TANs) play a critical role in modulating immune responses and exhibit significant heterogeneity. Our previous study demonstrated that jagged canonical Notch ligand 2 (JAG2)<sup>+</sup> TANs were associated with an immunosuppressive microenvironment in high-grade serous ovarian cancer (HGSOC), but the underlying mechanism remains unclear. This study aimed to elucidate the role of JAG2<sup>+</sup> TANs in tumor immunosuppressive microenvironment in HGSOC.<h4>Methods</h4>HGSOC samples were collected, with 274 samples constituting two independent cohorts (training and validation cohorts) and an additional 30 samples utilized to establish patient-derived tumor organoids (PDTOs). We characterized the number and phenotype of JAG2<sup>+</sup> TANs b"],"journal":["Cancer communications (London, England)"],"pubmed_title":["Immunosuppressive JAG2&lt;sup&gt;+&lt;/sup&gt; tumor-associated neutrophils hamper PD-1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells."],"pmcid":["PMC12328091"],"funding_grant_id":["82072881","82203665","23Y11901800","23ZR1408300","22MC1940200","82273205","82473274","23Y11909500"],"pubmed_authors":["Zhang G","Liu H","Cao K","Huang Y","Wang C","Yang M","Lu J","He M","Zhong Y","Wang X","Zhang C","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Immunosuppressive JAG2&lt;sup&gt;+&lt;/sup&gt; tumor-associated neutrophils hamper PD-1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells.","description":"<h4>Background</h4>Tumor-associated neutrophils (TANs) play a critical role in modulating immune responses and exhibit significant heterogeneity. Our previous study demonstrated that jagged canonical Notch ligand 2 (JAG2)<sup>+</sup> TANs were associated with an immunosuppressive microenvironment in high-grade serous ovarian cancer (HGSOC), but the underlying mechanism remains unclear. This study aimed to elucidate the role of JAG2<sup>+</sup> TANs in tumor immunosuppressive microenvironment in HGSOC.<h4>Methods</h4>HGSOC samples were collected, with 274 samples constituting two independent cohorts (training and validation cohorts) and an additional 30 samples utilized to establish patient-derived tumor organoids (PDTOs). We characterized the number and phenotype of JAG2<sup>+</sup> TANs b","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-07-15T12:45:21.293Z","creation":"2026-07-04T03:16:31.229Z"},"accession":"S-EPMC12328091","cross_references":{"pubmed":["40120139"],"doi":["10.1002/cac2.70021"]}}