{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cao S"],"funding":["National Research Foundation Singapore (National Research Foundation-Prime Minister's office, Republic of Singapore)"],"pagination":["7257"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12328705"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Lettuce (Lactuca sativa L.) is among the most widely cultivated and consumed vegetables globally, valued for its phytonutrients beneficial for human health. Here, we report the high-quality reference super-pangenome for the Lactuca genus by integrating 12 chromosome-scale genomes from representative cultivated lettuce morphotypes, landrace, and wild relatives, and investigate lettuce genome evolution and domestication. These assemblies exhibit diverse genome sizes ranging from 2.1 Gb to 5.5 Gb with abundant repetitive sequences, and expansion of repetitive sequences, associated with low DNA methylation levels, likely contributes to the genome size variations. Furthermore, by constructing a graph-based lettuce pangenome reference, we explore the landscape, genomic, and epigenetic features o"],"journal":["Nature communications"],"pubmed_title":["Lactuca super-pangenome provides insights into lettuce genome evolution and domestication."],"pmcid":["PMC12328705"],"funding_grant_id":["NRF-CRP22-2019-0001"],"pubmed_authors":["Shen L","Cao S","Sawettalake N"],"additional_accession":[]},"is_claimable":false,"name":"Lactuca super-pangenome provides insights into lettuce genome evolution and domestication.","description":"Lettuce (Lactuca sativa L.) is among the most widely cultivated and consumed vegetables globally, valued for its phytonutrients beneficial for human health. Here, we report the high-quality reference super-pangenome for the Lactuca genus by integrating 12 chromosome-scale genomes from representative cultivated lettuce morphotypes, landrace, and wild relatives, and investigate lettuce genome evolution and domestication. These assemblies exhibit diverse genome sizes ranging from 2.1 Gb to 5.5 Gb with abundant repetitive sequences, and expansion of repetitive sequences, associated with low DNA methylation levels, likely contributes to the genome size variations. Furthermore, by constructing a graph-based lettuce pangenome reference, we explore the landscape, genomic, and epigenetic features o","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-12T19:18:52.582Z","creation":"2026-04-07T13:17:45.046Z"},"accession":"S-EPMC12328705","cross_references":{"pubmed":["40770196"],"doi":["10.1038/s41467-025-62641-w"]}}