{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zheng S"],"funding":["Project of Anhui Rural Revitalization of Traditional Chinese Medicine Industry Collaborative Technology Service Center","West Anhui University High-Level Talent Research Start-up Funding","Provincial Level Nature Science Foundation of Anhui Education Department","Anhui Scientific Research and Innovation Team of Quality Evaluation and Improvement of Traditional Chinese Medicine"],"pagination":["e34"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12329059"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(4)"],"pubmed_abstract":["<h4>Importance</h4>Hyperuricemia (HUA) is a major metabolic disorder in poultry, leading to gout and kidney damage, which affects farm productivity. Accordingly, understanding the pharmacodynamics (PD) and pharmacokinetics (PK) of uric acid-lowering drugs is essential for improving the treatment strategies in poultry.<h4>Objective</h4>This study examined the PD and PK characteristics of allopurinol and benzbromarone, two uric acid-lowering drugs, in a quail model of HUA.<h4>Methods</h4>A hyperuricemic quail model was established using a high-purine diet. Allopurinol and benzbromarone were administered orally. Blood samples were taken and analyzed for the drug concentrations using high-performance liquid chromatography. Pathological examinations were conducted to assess kidney damage.<h4>Re"],"journal":["Journal of veterinary science"],"pubmed_title":["Comparison of pharmacokinetic and pharmacodynamic properties of allopurinol and benzbromarone in a quail model of hyperuricemia."],"pmcid":["PMC12329059"],"funding_grant_id":["GXXT-2022-079","2022AH010090","00701092394","2022AH051676"],"pubmed_authors":["Chen N","Bu Y","Li S","Zheng S"],"additional_accession":[]},"is_claimable":false,"name":"Comparison of pharmacokinetic and pharmacodynamic properties of allopurinol and benzbromarone in a quail model of hyperuricemia.","description":"<h4>Importance</h4>Hyperuricemia (HUA) is a major metabolic disorder in poultry, leading to gout and kidney damage, which affects farm productivity. Accordingly, understanding the pharmacodynamics (PD) and pharmacokinetics (PK) of uric acid-lowering drugs is essential for improving the treatment strategies in poultry.<h4>Objective</h4>This study examined the PD and PK characteristics of allopurinol and benzbromarone, two uric acid-lowering drugs, in a quail model of HUA.<h4>Methods</h4>A hyperuricemic quail model was established using a high-purine diet. Allopurinol and benzbromarone were administered orally. Blood samples were taken and analyzed for the drug concentrations using high-performance liquid chromatography. Pathological examinations were conducted to assess kidney damage.<h4>Re","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-05-02T02:48:43.921Z","creation":"2026-04-07T17:34:45.855Z"},"accession":"S-EPMC12329059","cross_references":{"pubmed":["40765224"],"doi":["10.4142/jvs.24313"]}}