biostudies-literatureZheng SProject of Anhui Rural Revitalization of Traditional Chinese Medicine Industry Collaborative Technology Service CenterWest Anhui University High-Level Talent Research Start-up FundingProvincial Level Nature Science Foundation of Anhui Education DepartmentAnhui Scientific Research and Innovation Team of Quality Evaluation and Improvement of Traditional Chinese Medicinee34https://www.ebi.ac.uk/biostudies/studies/S-EPMC12329059biostudies-literatureUnknown26(4)<h4>Importance</h4>Hyperuricemia (HUA) is a major metabolic disorder in poultry, leading to gout and kidney damage, which affects farm productivity. Accordingly, understanding the pharmacodynamics (PD) and pharmacokinetics (PK) of uric acid-lowering drugs is essential for improving the treatment strategies in poultry.<h4>Objective</h4>This study examined the PD and PK characteristics of allopurinol and benzbromarone, two uric acid-lowering drugs, in a quail model of HUA.<h4>Methods</h4>A hyperuricemic quail model was established using a high-purine diet. Allopurinol and benzbromarone were administered orally. Blood samples were taken and analyzed for the drug concentrations using high-performance liquid chromatography. Pathological examinations were conducted to assess kidney damage.<h4>ReJournal of veterinary scienceComparison of pharmacokinetic and pharmacodynamic properties of allopurinol and benzbromarone in a quail model of hyperuricemia.PMC12329059GXXT-2022-0792022AH010090007010923942022AH051676Chen NBu YLi SZheng SfalseComparison of pharmacokinetic and pharmacodynamic properties of allopurinol and benzbromarone in a quail model of hyperuricemia.<h4>Importance</h4>Hyperuricemia (HUA) is a major metabolic disorder in poultry, leading to gout and kidney damage, which affects farm productivity. Accordingly, understanding the pharmacodynamics (PD) and pharmacokinetics (PK) of uric acid-lowering drugs is essential for improving the treatment strategies in poultry.<h4>Objective</h4>This study examined the PD and PK characteristics of allopurinol and benzbromarone, two uric acid-lowering drugs, in a quail model of HUA.<h4>Methods</h4>A hyperuricemic quail model was established using a high-purine diet. Allopurinol and benzbromarone were administered orally. Blood samples were taken and analyzed for the drug concentrations using high-performance liquid chromatography. Pathological examinations were conducted to assess kidney damage.<h4>Re2025-01-01T00:00:00Z2025 Jul2026-05-02T02:48:43.921Z2026-04-07T17:34:45.855ZS-EPMC123290594076522410.4142/jvs.24313