{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lotti F"],"funding":["Fondazione Umberto Veronesi (Umberto Veronesi Foundation)","Associazione Italiana Ricerca sul Cancro","Ministero della Salute (Italy Ministry of Health)"],"pagination":["3804-3830"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12332017"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(15)"],"pubmed_abstract":["Melanoma exhibits high intratumoral heterogeneity, characterized by a diverse population of cells undergoing dynamic transitions between cellular states. These adaptive changes enable melanoma cells to survive in the harsh tumor microenvironment, acquire drug resistance, and metastasize. One such state, quiescence, has been linked to both relapse and drug resistance, but its underlying biology and molecular mechanisms remain poorly understood. Our study challenges the conventional understanding of melanoma quiescence. Contrary to the notion of a rare, unique subpopulation, we demonstrate that quiescence is a highly dynamic state accessible to most, if not all, melanoma cells. This state is exquisitely sensitive to microenvironmental cues. We identify GPNMB as a marker of quiescence, that is expressed in both primary and metastatic tumors. GPNMB-positive cells exhibit a pro-metastatic phenotype and are enriched in metastatic sites, suggesting a potential role for quiescence in tumor dissemination. Our findings position GPNMB as a valuable marker for isolating quiescent melanoma cells and as a potential therapeutic target to tackle metastasis."],"journal":["EMBO reports"],"pubmed_title":["GPNMB marks a quiescent cell population in melanoma and promotes metastasis formation."],"pmcid":["PMC12332017"],"funding_grant_id":["Fellowship","IG 2023 ID 28890","GR-2018-12367747","Ricerca Corrente and 5x1000 funds"],"pubmed_authors":["Barberis M","Malferrari M","Quaresima N","Nobile MS","Bacciu L","Rapino S","Marocchi F","Mollo V","Ferrucci PF","Ferrarotto I","Bossi D","Lotti F","Melixetian M","Gallo B","Pelicci PG","Lanfrancone L","Vlachou T","Soriani C","Luzi L"],"additional_accession":[]},"is_claimable":false,"name":"GPNMB marks a quiescent cell population in melanoma and promotes metastasis formation.","description":"Melanoma exhibits high intratumoral heterogeneity, characterized by a diverse population of cells undergoing dynamic transitions between cellular states. These adaptive changes enable melanoma cells to survive in the harsh tumor microenvironment, acquire drug resistance, and metastasize. One such state, quiescence, has been linked to both relapse and drug resistance, but its underlying biology and molecular mechanisms remain poorly understood. Our study challenges the conventional understanding of melanoma quiescence. Contrary to the notion of a rare, unique subpopulation, we demonstrate that quiescence is a highly dynamic state accessible to most, if not all, melanoma cells. This state is exquisitely sensitive to microenvironmental cues. We identify GPNMB as a marker of quiescence, that is expressed in both primary and metastatic tumors. GPNMB-positive cells exhibit a pro-metastatic phenotype and are enriched in metastatic sites, suggesting a potential role for quiescence in tumor dissemination. Our findings position GPNMB as a valuable marker for isolating quiescent melanoma cells and as a potential therapeutic target to tackle metastasis.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-15T19:17:04.767Z","creation":"2026-04-07T14:01:13.853Z"},"accession":"S-EPMC12332017","cross_references":{"pubmed":["40528051"],"doi":["10.1038/s44319-025-00501-w"]}}