biostudies-literatureKe BTianjin Key Medical Discipline(Specialty) Construction ProjectNational Natural Science Foundation of China28934https://www.ebi.ac.uk/biostudies/studies/S-EPMC12332073biostudies-literatureUnknown15(1)Integrin subunit alpha V (ITGAV), a subunit of the integrin receptor, is involved in many types of cancers. In order to explore the potential mechanisms of ITGAV in cancers, we carried out a comprehensive pan-cancer analysis using public database. In this study, ITGAV expression in different cancers and the relationship between ITGAV and clinic-pathological features, prognosis, genetic alteration, epigenetic modification, and tumor immune microenvironment were systemically analyzed. Gene enrichment analysis was performed to explore potential functions of ITGAV in gastric cancer (GC). GC tissue microarrays and in vitro cell experiments were used to verify the prediction results in GC. The results revealed that ITGAV was variably expression in different cancers, and ITGAV had a certain prognScientific reportsPan-cancer landscape of ITGAV and its potential role in gastric cancer.PMC1233207381401952TJYXZDXK-009ALiu NZhang RPJin PWang XJKe BMa GfalsePan-cancer landscape of ITGAV and its potential role in gastric cancer.Integrin subunit alpha V (ITGAV), a subunit of the integrin receptor, is involved in many types of cancers. In order to explore the potential mechanisms of ITGAV in cancers, we carried out a comprehensive pan-cancer analysis using public database. In this study, ITGAV expression in different cancers and the relationship between ITGAV and clinic-pathological features, prognosis, genetic alteration, epigenetic modification, and tumor immune microenvironment were systemically analyzed. Gene enrichment analysis was performed to explore potential functions of ITGAV in gastric cancer (GC). GC tissue microarrays and in vitro cell experiments were used to verify the prediction results in GC. The results revealed that ITGAV was variably expression in different cancers, and ITGAV had a certain progn2025-01-01T00:00:00Z2025 Aug2026-05-01T08:38:14.808Z2026-04-19T03:07:57.059ZS-EPMC123320734077543110.1038/s41598-025-14342-z