{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schmidiger S"],"funding":["Swiss National Science Foundation","European & Developing Countries Clinical Trials Partnership (EDCTP)"],"pagination":["e70004"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12332329"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["55(8)"],"pubmed_abstract":["Human tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains a global public health threat. Granulomas constitute a hallmark of TB pathogenesis that can clear, contain, or exacerbate an infection. Containment is exploited by Mtb as a hideout to persist in a dormant, antibiotic-tolerant state, only to resuscitate upon immunosuppression. The immune determinants of a granulomatous response driving Mtb persistence remain elusive. We here generated ex vivo granuloma-like structures from peripheral blood mononuclear cell specimens of TB patients and applied high-dimensional mass cytometry to elucidate immune factors prompting Mtb dormancy. Compared with healthy controls, patient-derived specimens rapidly forced Mtb to become dormant-like ex vivo. This observation correlated with an"],"journal":["European journal of immunology"],"pubmed_title":["Granulysin Antimicrobial Activity Promotes Dormancy in Mycobacterium tuberculosis."],"pmcid":["PMC12332329"],"funding_grant_id":["197838 and 177163"],"pubmed_authors":["Mfinanga E","McCaffrey EF","Haraka F","Reither K","Sasamalo M","Hameed OA","Hiza H","Hella J","Walch M","Fellay J","Gagneux S","Schmidt JM","Tumbo A","Portevin D","Schmidiger S","Carballido JM","Arbues A","Mpina M"],"additional_accession":[]},"is_claimable":false,"name":"Granulysin Antimicrobial Activity Promotes Dormancy in Mycobacterium tuberculosis.","description":"Human tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains a global public health threat. Granulomas constitute a hallmark of TB pathogenesis that can clear, contain, or exacerbate an infection. Containment is exploited by Mtb as a hideout to persist in a dormant, antibiotic-tolerant state, only to resuscitate upon immunosuppression. The immune determinants of a granulomatous response driving Mtb persistence remain elusive. We here generated ex vivo granuloma-like structures from peripheral blood mononuclear cell specimens of TB patients and applied high-dimensional mass cytometry to elucidate immune factors prompting Mtb dormancy. Compared with healthy controls, patient-derived specimens rapidly forced Mtb to become dormant-like ex vivo. This observation correlated with an","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-15T19:07:53.17Z","creation":"2026-04-07T14:00:53.686Z"},"accession":"S-EPMC12332329","cross_references":{"pubmed":["40776481"],"doi":["10.1002/eji.70004"]}}