biostudies-literatureKoshiol JAcademia Sinica833-842https://www.ebi.ac.uk/biostudies/studies/S-EPMC12332984biostudies-literatureUnknown54(6)<h4>Background</h4>Clinical and experimental studies suggest immunologic proteins contribute to hepatocellular carcinoma (HCC) development.<h4>Aim</h4>To evaluate circulating immunologic markers and HCC risk.<h4>Methods</h4>From a Taiwanese cohort of chronically hepatitis B virus (HBV)-infected individuals followed over time (REVEAL-HBV), we sampled 175 who developed HCC, 117 cirrhosis only, and 165 non-cirrhotic controls. From a similar Taiwanese cohort of chronically hepatitis C virus (HCV)-infected individuals (REVEAL-HCV), we included 94 individuals who developed HCC, 68 cirrhosis only and 100 non-cirrhotic controls. We compared pre-diagnostic plasma levels of 102 markers in HCC cases to non-cirrhotic and cirrhotic controls using polytomous logistic regression. A priori markers includeAlimentary pharmacology & therapeuticsImmunologic markers and risk of hepatocellular carcinoma in hepatitis B virus- and hepatitis C virus-infected individuals.PMC12332984101‐2314‐B‐001‐005‐MY3Lee MHChen CJMcGlynn KAO'Brien TRYu KYang HILiu ZPetrick JLPfeiffer RMKoshiol JArgirion IKim Lam TPinto LHildesheim AfalseImmunologic markers and risk of hepatocellular carcinoma in hepatitis B virus- and hepatitis C virus-infected individuals.<h4>Background</h4>Clinical and experimental studies suggest immunologic proteins contribute to hepatocellular carcinoma (HCC) development.<h4>Aim</h4>To evaluate circulating immunologic markers and HCC risk.<h4>Methods</h4>From a Taiwanese cohort of chronically hepatitis B virus (HBV)-infected individuals followed over time (REVEAL-HBV), we sampled 175 who developed HCC, 117 cirrhosis only, and 165 non-cirrhotic controls. From a similar Taiwanese cohort of chronically hepatitis C virus (HCV)-infected individuals (REVEAL-HCV), we included 94 individuals who developed HCC, 68 cirrhosis only and 100 non-cirrhotic controls. We compared pre-diagnostic plasma levels of 102 markers in HCC cases to non-cirrhotic and cirrhotic controls using polytomous logistic regression. A priori markers include2021-01-01T00:00:00Z2021 Sep2026-04-15T19:22:08.9Z2026-04-07T14:01:03.019ZS-EPMC123329843428685110.1111/apt.16524