{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(32)"],"submitter":["Dhand AP"],"pubmed_abstract":["Light-mediated manipulation of hydrogel physicochemical properties is attractive for numerous applications, yet the processing of such hydrogels via vat photopolymerization [e.g., digital light processing (DLP)] is challenging as photoresponsive chemistries may be consumed during printing. Here, we report a facile strategy to DLP print hydrogels that combines short light exposures to set the shape of a printed object and complementary dark polymerization to continue the reaction of macromers without disturbing photoresponsive groups. Postprinting, hydrogels are then programmed using single- or multiphoton light and photoinitiator-free reactions: tetrazole-alkene click reaction (for photofunctionalization), dithiolane ring-opening polymerization (for photostiffening), and o-nitrobenzyl clea"],"journal":["Science advances"],"pagination":["eadw9262"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12333685"],"repository":["biostudies-literature"],"pubmed_title":["Digital light processing of photoresponsive and programmable hydrogels."],"pmcid":["PMC12333685"],"pubmed_authors":["Kirkpatrick BE","Dhand AP","Meurer-Zeman B","Mandal A","Anseth KS","Bowman CN","Nelson BR","Lee JS","Miksch CE","Cione J","Burdick JA","Garay-Sarmiento M","Zlotnick HM"],"additional_accession":[]},"is_claimable":false,"name":"Digital light processing of photoresponsive and programmable hydrogels.","description":"Light-mediated manipulation of hydrogel physicochemical properties is attractive for numerous applications, yet the processing of such hydrogels via vat photopolymerization [e.g., digital light processing (DLP)] is challenging as photoresponsive chemistries may be consumed during printing. Here, we report a facile strategy to DLP print hydrogels that combines short light exposures to set the shape of a printed object and complementary dark polymerization to continue the reaction of macromers without disturbing photoresponsive groups. Postprinting, hydrogels are then programmed using single- or multiphoton light and photoinitiator-free reactions: tetrazole-alkene click reaction (for photofunctionalization), dithiolane ring-opening polymerization (for photostiffening), and o-nitrobenzyl clea","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-01T08:49:51.018Z","creation":"2026-04-07T16:46:26.272Z"},"accession":"S-EPMC12333685","cross_references":{"pubmed":["40779636"],"doi":["10.1126/sciadv.adw9262"]}}