{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kostritskaia Y"],"funding":["Bundesministerium für Bildung und Forschung (BMBF)"],"pagination":["4329-4344"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12333907"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["603(15)"],"pubmed_abstract":["Volume-regulated anion channels (VRACs) formed by leucin-rich repeat containing 8 (LRRC8) proteins play a pivotal role in regulatory volume decrease by mediating the release of chloride and organic osmolytes. Apart from the regulation of cell volume, LRRC8/VRAC function underlies numerous physiological processes in vertebrate cells including membrane potential regulation, glutamate release and apoptosis. LRRC8/VRACs are also permeable to antibiotics and anti-cancer drugs, representing therefore important therapeutic targets. The activation mechanisms for LRRC8/VRACs are still unclear. Besides through osmotic cell swelling, LRRC8/VRACs can be activated by various stimuli under isovolumetric conditions. Sphingosine-1-phosphate (S1P), an important signalling lipid, which signals through a fam"],"journal":["The Journal of physiology"],"pubmed_title":["Sphingosine-1-phosphate activates LRRC8 volume-regulated anion channels through Gβγ signalling."],"pmcid":["PMC12333907"],"funding_grant_id":["031A314"],"pubmed_authors":["Klemmer A","Kostritskaia Y","Pervaiz S","Klussendorf M","Stauber T"],"additional_accession":[]},"is_claimable":false,"name":"Sphingosine-1-phosphate activates LRRC8 volume-regulated anion channels through Gβγ signalling.","description":"Volume-regulated anion channels (VRACs) formed by leucin-rich repeat containing 8 (LRRC8) proteins play a pivotal role in regulatory volume decrease by mediating the release of chloride and organic osmolytes. Apart from the regulation of cell volume, LRRC8/VRAC function underlies numerous physiological processes in vertebrate cells including membrane potential regulation, glutamate release and apoptosis. LRRC8/VRACs are also permeable to antibiotics and anti-cancer drugs, representing therefore important therapeutic targets. The activation mechanisms for LRRC8/VRACs are still unclear. Besides through osmotic cell swelling, LRRC8/VRACs can be activated by various stimuli under isovolumetric conditions. Sphingosine-1-phosphate (S1P), an important signalling lipid, which signals through a fam","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-01T08:40:22Z","creation":"2026-04-19T03:08:09.523Z"},"accession":"S-EPMC12333907","cross_references":{"pubmed":["39496493"],"doi":["10.1113/JP286665"]}}