{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["104(7)"],"submitter":["Tran Quang V"],"pubmed_abstract":["The present longitudinal study reports a unique patient followed over almost three decades who sequentially developed polycythemia vera, chronic myelomonocytic leukemia, and chronic myeloid leukemia. The patient received successive hydroxyurea, ruxolitinib, and a combination of ruxolitinib and nilotinib. The clonal architecture dynamic was reconstructed using targeted high throughput asymmetric capture sequencing, allowing detection and quantification of mutations in 43 myeloid genes and BCR::ABL1 fusion in multiple bone marrow or peripheral blood samples and in single cell-derived colonies obtained from bone marrow colony-forming cell assays. This analysis has uncovered an unexpected subclonal link between three myeloid malignancies, all stemming from a DNMT3A/TET2 double mutant clone. Ov"],"journal":["Annals of hematology"],"pagination":["3881-3887"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12334534"],"repository":["biostudies-literature"],"pubmed_title":["Subclonal emergence of polycythemia vera, chronic myelomonocytic leukemia, and chronic myeloid leukemia."],"pmcid":["PMC12334534"],"pubmed_authors":["Etancelin P","Wagner-Ballon O","Sloma I","Barathon Q","Cretin J","Joy C","Pautas C","Loyaux R","Ben Jedidia B","Gricourt G","Tran Quang V","Tarfi S","Roy L"],"additional_accession":[]},"is_claimable":false,"name":"Subclonal emergence of polycythemia vera, chronic myelomonocytic leukemia, and chronic myeloid leukemia.","description":"The present longitudinal study reports a unique patient followed over almost three decades who sequentially developed polycythemia vera, chronic myelomonocytic leukemia, and chronic myeloid leukemia. The patient received successive hydroxyurea, ruxolitinib, and a combination of ruxolitinib and nilotinib. The clonal architecture dynamic was reconstructed using targeted high throughput asymmetric capture sequencing, allowing detection and quantification of mutations in 43 myeloid genes and BCR::ABL1 fusion in multiple bone marrow or peripheral blood samples and in single cell-derived colonies obtained from bone marrow colony-forming cell assays. This analysis has uncovered an unexpected subclonal link between three myeloid malignancies, all stemming from a DNMT3A/TET2 double mutant clone. Ov","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-04-15T19:07:45.913Z","creation":"2026-04-07T14:00:51.862Z"},"accession":"S-EPMC12334534","cross_references":{"pubmed":["40411597"],"doi":["10.1007/s00277-025-06417-8"]}}