{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yan F"],"funding":["the Natural Science Foundation of Shandong Province","Research Fund for Lin He's Academician Workstation of New Medicine and Clinical Translation at Jining Medical University","Project of Medical and Health Technology Development Program in Shandong Province","National Natural Science Foundation of China","Shandong Training Program of Innovation and Entrepreneurship for Undergraduates","Project of Shandong Province Higher Educational Youth Innovation Science and Technology Program","Tai Shan Young Scholar Foundation of Shandong Province","Research Fund for Lin He’s Academician Workstation of New Medicine and Clinical Translation at Jining Medical University"],"pagination":["2274-2291"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12336090"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["48(4)"],"pubmed_abstract":["Sappanone A (SAP), a high-isoflavone compound derived from the traditional Chinese medicine Sumu, exhibits various pharmacological activities, including anti-inflammatory and anti-oxidant effects. However, its protective effects on the liver have rarely been reported. The aim of this study was to investigate the effects of SAP on immune-mediated liver injury induced by concanavalin A (Con A) in mice and to explore the underlying molecular mechanisms. Mice were administered SAP intraperitoneally (50 mg/kg body weight). Three hours later, Con A (18 mg/kg) was injected via the tail vein to induce liver damage. Livers and blood were collected 12 h after Con A challenge. Liver cell apoptosis, oxidative stress, and M1 macrophage activation in vivo were investigated. Bone marrow-derived macrophag"],"journal":["Inflammation"],"pubmed_title":["Sappanone A Ameliorates Concanavalin A-induced Immune-Mediated Liver Injury by Regulating M1 Macrophage Polarization."],"pmcid":["PMC12336090"],"funding_grant_id":["S202410443201","82171810","202202070388","JYHL2022MS21","ZR2021MH287","ZR2023QH332","tsqn202211234","202202050678","2021KJ074"],"pubmed_authors":["Guo Z","Li C","Zhang J","Wang C","Zhang H","Sun X","Zhong Z","Wang L","Li W","Liu Z","Dong G","Gao M","Chen S","Yan F","Xiong H"],"additional_accession":[]},"is_claimable":false,"name":"Sappanone A Ameliorates Concanavalin A-induced Immune-Mediated Liver Injury by Regulating M1 Macrophage Polarization.","description":"Sappanone A (SAP), a high-isoflavone compound derived from the traditional Chinese medicine Sumu, exhibits various pharmacological activities, including anti-inflammatory and anti-oxidant effects. However, its protective effects on the liver have rarely been reported. The aim of this study was to investigate the effects of SAP on immune-mediated liver injury induced by concanavalin A (Con A) in mice and to explore the underlying molecular mechanisms. Mice were administered SAP intraperitoneally (50 mg/kg body weight). Three hours later, Con A (18 mg/kg) was injected via the tail vein to induce liver damage. Livers and blood were collected 12 h after Con A challenge. Liver cell apoptosis, oxidative stress, and M1 macrophage activation in vivo were investigated. Bone marrow-derived macrophag","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-30T14:37:20.065Z","creation":"2026-04-07T16:03:40.376Z"},"accession":"S-EPMC12336090","cross_references":{"pubmed":["39589634"],"doi":["10.1007/s10753-024-02189-x"]}}