biostudies-literatureUnknown15(8)Tiemes VBMJ openhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC12336530biostudies-literatureHotspotters Project: a study protocol for a stepped wedge cluster RCT on the cost-effectiveness of 12-month proactive, integrated and personalised care for patients with problems on multiple life domains and high acute care usePMC12336530van Gestel LNumans MLeming KBruijnzeels Mvan den Akker-van Marle ETiemes Vvan der Wel MVos RBorgdorff HAdriaanse MfalseHotspotters Project: a study protocol for a stepped wedge cluster RCT on the cost-effectiveness of 12-month proactive, integrated and personalised care for patients with problems on multiple life domains and high acute care use2025-01-01T00:00:00Z2025 Jan2026-05-29T16:32:12.38Z2026-04-08T05:25:14.231ZS-EPMC12336530