{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Brodsky NN"],"funding":["Yale University (Yale)","HHS | NIH | NIAID | Division of Intramural Research (DIR, NIAID)","NICHD NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["e2421106122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12337316"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["122(31)"],"pubmed_abstract":["Neonates and infants are distinct in their clinical and cellular responses to viral infections, with neonatal CD8<sup>+</sup> T cells displaying innate-like characteristics and a low threshold for T cell receptor activation. However, specific molecular programs that drive these unique responses are incompletely understood, particularly in humans, and targetable pathways to modulate viral illness in this vulnerable population remain to be elucidated. Early-life immune responses may be developmentally programmed to prioritize avoidance of tissue immunopathology, especially while maternal immunoglobulin provides passive immunity. We set out to define the unique response characteristics and transcription factor landscape of neonatal human CD8<sup>+</sup> T cells. Here, we report evidence that "],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Early-life human CD8&lt;sup&gt;+&lt;/sup&gt; T cells exhibit rapid, short-lived effector responses and a unique transcription factor landscape."],"pmcid":["PMC12337316"],"funding_grant_id":["N/A","Multiple","R00 HL125668","K08 AI177743","R21 HD102565","T32 GM136651"],"pubmed_authors":["Lucas CL","Kumar DBU","Brodsky NN","Barmada A","Ramaswamy A","Gu W","Chakder M","Wats A","Konnikova L","Olaloye O","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"Early-life human CD8&lt;sup&gt;+&lt;/sup&gt; T cells exhibit rapid, short-lived effector responses and a unique transcription factor landscape.","description":"Neonates and infants are distinct in their clinical and cellular responses to viral infections, with neonatal CD8<sup>+</sup> T cells displaying innate-like characteristics and a low threshold for T cell receptor activation. However, specific molecular programs that drive these unique responses are incompletely understood, particularly in humans, and targetable pathways to modulate viral illness in this vulnerable population remain to be elucidated. Early-life immune responses may be developmentally programmed to prioritize avoidance of tissue immunopathology, especially while maternal immunoglobulin provides passive immunity. We set out to define the unique response characteristics and transcription factor landscape of neonatal human CD8<sup>+</sup> T cells. Here, we report evidence that ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-15T06:10:56.03Z","creation":"2026-06-15T03:08:59.464Z"},"accession":"S-EPMC12337316","cross_references":{"pubmed":["40720649"],"doi":["10.1073/pnas.2421106122"]}}