biostudies-literatureEngland BRBLRD VARRD VAHSRD VANIAMS NIH HHSNIGMS NIH HHSCSRD VAe166-e177https://www.ebi.ac.uk/biostudies/studies/S-EPMC12337451biostudies-literatureUnknown7(3)<h4>Background</h4>Uncertainty exists regarding patient outcomes when using TNF inhibitors versus other biological and targeted synthetic disease-modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis-associated interstitial lung disease (ILD). We compared survival and respiratory hospitalisation outcomes following initiation of TNF-inhibitor or non-TNF inhibitor biological or targeted synthetic DMARDs for treatment of rheumatoid arthritis-associated ILD.<h4>Methods</h4>We did a retrospective, active-comparator, new-user, observational cohort study with propensity score matching following the target trial emulation framework using US Department of Veterans Affairs (VA) electronic and administrative health records. VA health-care enrollees with rheumatoid arthritis-associated ILD anThe Lancet. RheumatologyAdvanced therapies in US veterans with rheumatoid arthritis-associated interstitial lung disease: a retrospective, active-comparator, new-user, cohort study.PMC12337451I01 RX003644P30 AR072583I01 BX004660P20 GM130423I01 CX001703SDR 02-237U54 GM115458IK2 CX002203Frideres HRoul PRojas JSauer BCBaker JFEngland BRJohnson TMYu FMikuls TRCurtis JRSayles HMatson SMYang YGeorge MDCannon GWfalseAdvanced therapies in US veterans with rheumatoid arthritis-associated interstitial lung disease: a retrospective, active-comparator, new-user, cohort study.<h4>Background</h4>Uncertainty exists regarding patient outcomes when using TNF inhibitors versus other biological and targeted synthetic disease-modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis-associated interstitial lung disease (ILD). We compared survival and respiratory hospitalisation outcomes following initiation of TNF-inhibitor or non-TNF inhibitor biological or targeted synthetic DMARDs for treatment of rheumatoid arthritis-associated ILD.<h4>Methods</h4>We did a retrospective, active-comparator, new-user, observational cohort study with propensity score matching following the target trial emulation framework using US Department of Veterans Affairs (VA) electronic and administrative health records. VA health-care enrollees with rheumatoid arthritis-associated ILD an2025-01-01T00:00:00Z2025 Mar2026-06-06T10:55:20.834Z2026-05-29T03:12:47.654ZS-EPMC123374513979359810.1016/s2665-9913(24)00265-010.1016/S2665-9913(24)00265-0