biostudies-literatureUnknown36(8)Hirokami JThe EU-PORIA registry was supported by a research grant from Boston Scientific.<h4>Background</h4>Real-life data on efficacy and safety of pulsed-field ablation (PFA) using the pentaspline multi-electrode catheter in symptomatic atrial fibrillation (AF) patients is still scarce.<h4>Objective</h4>This study aims to assess the efficacy and safety of PFA in patients with persistent AF.<h4>Methods</h4>Data from early commercial use across seven European centers were collected in a registry. To confirm the efficacy and safety of extra pulmonary vein (PV) ablation, patients were categorized into two groups: those undergoing pulmonary vein isolation (PVI) alone and those receiving additional ablation. Procedural and follow-up data were collected.<h4>Results</h4>The study included 448 patients (347 PVI only, 101 PVI + α). In the PVI + α group, extra PV ablation included leftJournal of cardiovascular electrophysiology1710-1720https://www.ebi.ac.uk/biostudies/studies/S-EPMC12337630biostudies-literaturePulsed-Field Ablation for Persistent Atrial Fibrillation in EU-PORIA Registry.PMC12337630Tohoku SAdelino RSchmidt BFuting AMene RReinsch NBlaauw YHirokami JReichlin TOuss ABordignon Svan der Voort PRuwald MHRoten LBoveda SChun KRJMulder BAKueffer TAlbrecht EMHansen JNeven KfalsePulsed-Field Ablation for Persistent Atrial Fibrillation in EU-PORIA Registry.<h4>Background</h4>Real-life data on efficacy and safety of pulsed-field ablation (PFA) using the pentaspline multi-electrode catheter in symptomatic atrial fibrillation (AF) patients is still scarce.<h4>Objective</h4>This study aims to assess the efficacy and safety of PFA in patients with persistent AF.<h4>Methods</h4>Data from early commercial use across seven European centers were collected in a registry. To confirm the efficacy and safety of extra pulmonary vein (PV) ablation, patients were categorized into two groups: those undergoing pulmonary vein isolation (PVI) alone and those receiving additional ablation. Procedural and follow-up data were collected.<h4>Results</h4>The study included 448 patients (347 PVI only, 101 PVI + α). In the PVI + α group, extra PV ablation included left2025-01-01T00:00:00Z2025 Aug2026-04-30T14:41:40.197Z2026-04-07T16:03:36.263ZS-EPMC123376304017179710.1111/jce.16583