biostudies-literatureUnknown66(11)Wu Y<h4>Purpose</h4>To investigate the arrangement and orientation of the collagen fibers in the inner and outer scleral layers at the edges of posterior staphylomas using polarization-sensitive optical coherence tomography (PS-OCT).<h4>Methods</h4>This observational case series study enrolled 105 patients with high myopia (refractive error <-6.0 diopters or axial length ≥26.5 mm) who underwent PS-OCT examinations between August 2023 and May 2024 at the Institute of Science Tokyo. Posterior staphyloma was diagnosed in 88 eyes of 60 patients using ultra-widefield OCT, followed by PS-OCT image processing. Thirty-six eyes from 27 patients with clearly identifiable staphyloma edges were included for final analysis. PS-OCT images were analyzed to assess the scleral fiber orientation and birefringenInvestigative ophthalmology & visual science6https://www.ebi.ac.uk/biostudies/studies/S-EPMC12338364biostudies-literaturePolarization-Sensitive Optical Coherence Tomography Imaging of Posterior Staphyloma Edges in Eyes With High Myopia.PMC12338364Xiong JOkamoto MYamanari MChen CSugisawa KKamoi KTakahashi TLu HOhno-Matsui KWang YWang ZWu YTakahashi HfalsePolarization-Sensitive Optical Coherence Tomography Imaging of Posterior Staphyloma Edges in Eyes With High Myopia.<h4>Purpose</h4>To investigate the arrangement and orientation of the collagen fibers in the inner and outer scleral layers at the edges of posterior staphylomas using polarization-sensitive optical coherence tomography (PS-OCT).<h4>Methods</h4>This observational case series study enrolled 105 patients with high myopia (refractive error <-6.0 diopters or axial length ≥26.5 mm) who underwent PS-OCT examinations between August 2023 and May 2024 at the Institute of Science Tokyo. Posterior staphyloma was diagnosed in 88 eyes of 60 patients using ultra-widefield OCT, followed by PS-OCT image processing. Thirty-six eyes from 27 patients with clearly identifiable staphyloma edges were included for final analysis. PS-OCT images were analyzed to assess the scleral fiber orientation and birefringen2025-01-01T00:00:00Z2025 Aug2026-05-04T15:24:47.893Z2026-04-07T20:38:44.725ZS-EPMC123383644076254110.1167/iovs.66.11.6