biostudies-literatureUnknown14(8)Li J<h4>Purpose</h4>The purpose of this study was to identify novel features on spectral-domain optical coherence tomography angiography (SD-OCTA) that improve detection of polypoidal lesions in polypoidal choroidal vasculopathy (PCV).<h4>Methods</h4>In this prospective study, 22 eyes from 20 patients with indocyanine green angiography (ICGA) confirmed PCV underwent same-day imaging with both SD-OCTA and swept-source OCTA (SS-OCTA). Images were independently reviewed, and blinded to ICGA and each other. Morphological features of polypoidal lesions were compared to establish combined diagnostic criteria to improve SD-OCTA detection, including hyper- or hypo-flow signals on angiographic en face images, circular hypo-reflective signals on structural en face images, and corresponding flow signals Translational vision science & technology12https://www.ebi.ac.uk/biostudies/studies/S-EPMC12338367biostudies-literatureCombining Hypo-Reflective Structural En Face Imaging Improves Polypoidal Lesion Detection on Spectral-Domain OCT Angiography.PMC12338367Zhou MShen MBo QXu NLi JJia HWang FWan XSun XfalseCombining Hypo-Reflective Structural En Face Imaging Improves Polypoidal Lesion Detection on Spectral-Domain OCT Angiography.<h4>Purpose</h4>The purpose of this study was to identify novel features on spectral-domain optical coherence tomography angiography (SD-OCTA) that improve detection of polypoidal lesions in polypoidal choroidal vasculopathy (PCV).<h4>Methods</h4>In this prospective study, 22 eyes from 20 patients with indocyanine green angiography (ICGA) confirmed PCV underwent same-day imaging with both SD-OCTA and swept-source OCTA (SS-OCTA). Images were independently reviewed, and blinded to ICGA and each other. Morphological features of polypoidal lesions were compared to establish combined diagnostic criteria to improve SD-OCTA detection, including hyper- or hypo-flow signals on angiographic en face images, circular hypo-reflective signals on structural en face images, and corresponding flow signals 2025-01-01T00:00:00Z2025 Aug2026-04-18T11:16:12.729Z2026-04-07T14:34:33.14ZS-EPMC123383674076253510.1167/tvst.14.8.12