{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(8)"],"submitter":["Du RL"],"funding":["Hong Kong Polytechnic University","Innovation and Technology Commission"],"pubmed_abstract":["The rapid increase in bacterial resistance to conventional antibiotics has led to a great demand for novel antibacterial agents. Antimicrobial peptides (AMPs) are emerging as next-generation antimicrobial alternative drugs to conventional antibiotics because of their broad-spectrum antimicrobial activities and minimal potential for drug resistance induction. This work describes novel antimicrobial peptides (FtsZpcpp) synthesized through the conjugation of a cell penetration peptide ((RXR)<sub>4</sub>XB) to nonantimicrobial peptides (FtsZp). The FtsZp peptides were previously identified to bind FtsZ (flaming-temperature-sensitive protein Z), a crucial protein in regulating bacterial cell divisions. Newly designed FtsZpcpp peptides have broad antimicrobial activities against both Gram-positi"],"journal":["ACS infectious diseases"],"pagination":["2190-2204"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12340945"],"repository":["biostudies-literature"],"pubmed_title":["Development of Broad-Spectrum Antimicrobial Peptides through the Conjugation of FtsZ-Binding and Cell-Penetrating Peptides."],"pmcid":["PMC12340945"],"pubmed_authors":["Chan PH","Kong WP","Wong KY","Du RL","Hung CH","Liang ZG","Wang Y","Ding K","Leung AS"],"additional_accession":[]},"is_claimable":false,"name":"Development of Broad-Spectrum Antimicrobial Peptides through the Conjugation of FtsZ-Binding and Cell-Penetrating Peptides.","description":"The rapid increase in bacterial resistance to conventional antibiotics has led to a great demand for novel antibacterial agents. Antimicrobial peptides (AMPs) are emerging as next-generation antimicrobial alternative drugs to conventional antibiotics because of their broad-spectrum antimicrobial activities and minimal potential for drug resistance induction. This work describes novel antimicrobial peptides (FtsZpcpp) synthesized through the conjugation of a cell penetration peptide ((RXR)<sub>4</sub>XB) to nonantimicrobial peptides (FtsZp). The FtsZp peptides were previously identified to bind FtsZ (flaming-temperature-sensitive protein Z), a crucial protein in regulating bacterial cell divisions. Newly designed FtsZpcpp peptides have broad antimicrobial activities against both Gram-positi","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-01T03:33:19.835Z","creation":"2026-04-07T16:35:46.946Z"},"accession":"S-EPMC12340945","cross_references":{"pubmed":["40707007"],"doi":["10.1021/acsinfecdis.5c00220"]}}