{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shi Y"],"funding":["Japan Agency for Medical Research and Development","Japan Science and Technology Agency","Japan Society for the Promotion of Science"],"pagination":["8580-8585"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12340962"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(31)"],"pubmed_abstract":["Genome mining of polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) in fungal endophyte <i>Neopestalotiopsis olumideae</i> strain BRIP 39872 identified seven new natural products (olumilides A-D, D1, D1', D2) with pyrano[2,3-<i>c</i>]pyrrole scaffolds and their biosynthetic precursor preolumilide. Unlike known congeners, such as curvupallides, olumilides possess alkyl side chains with branched methyl groups and threonine-derived core scaffolds. Absolute configurations were determined by microED and ECD simulations, providing valuable information for further research focusing on the stereochemistry of PKS-NRPS reactions."],"journal":["Organic letters"],"pubmed_title":["Genome Mining-Based Discovery of Pyrano[2,3-&lt;i&gt;c&lt;/i&gt;]pyrrole Type Natural Products Possessing Alkyl Side Chain with Branched Methyl Groups."],"pmcid":["PMC12340962"],"funding_grant_id":["JP24ama121040","JPMJAN23D4","JP22H02775","JP24ama121038","JPMJFR205W","JP23gm1610007"],"pubmed_authors":["Fukano H","Asai T","Suzuki M","Kodama EN","Matsuda R","Hoshino Y","Shimotai Y","Aoyama Y","Davis RA","Ozaki T","Taniguchi T","Fuse T","Shi Y","Yasuda J","Numata K","Yoshikawa R","Hayashi H","Hamamoto H","Morishita Y","Hirabayashi A","Hosotani K","Sato H","Sugawara A"],"additional_accession":[]},"is_claimable":false,"name":"Genome Mining-Based Discovery of Pyrano[2,3-&lt;i&gt;c&lt;/i&gt;]pyrrole Type Natural Products Possessing Alkyl Side Chain with Branched Methyl Groups.","description":"Genome mining of polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) in fungal endophyte <i>Neopestalotiopsis olumideae</i> strain BRIP 39872 identified seven new natural products (olumilides A-D, D1, D1', D2) with pyrano[2,3-<i>c</i>]pyrrole scaffolds and their biosynthetic precursor preolumilide. Unlike known congeners, such as curvupallides, olumilides possess alkyl side chains with branched methyl groups and threonine-derived core scaffolds. Absolute configurations were determined by microED and ECD simulations, providing valuable information for further research focusing on the stereochemistry of PKS-NRPS reactions.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-16T15:09:22.422Z","creation":"2026-04-07T14:12:58.07Z"},"accession":"S-EPMC12340962","cross_references":{"pubmed":["40776698"],"doi":["10.1021/acs.orglett.5c02504"]}}