{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(7)"],"submitter":["Tsoi SK"],"funding":["Royal Children's Hospital Foundation","Roche Diagnostics Australia and Siemens Healthineers Australia","Royal Children&apos;s Hospital Foundation"],"pubmed_abstract":["<h4>Background</h4>Diagnostic criteria for acute rheumatic fever and post-streptococcal glomerulonephritis, the 2 major autoimmune complications of Streptococcus pyogenes infection, include serological evidence of preceding infection. The S. pyogenes proteins, namely streptolysin O and deoxyribonuclease B, are the most widely used targets for clinical streptococcal serology. We aimed to establish age-based reference intervals (RIs) for healthy children in Victoria, Australia, to guide interpretation of anti-streptolysin O (ASO) levels measured by turbidimetry and nephelometry, and anti-deoxyribonuclease B (ADB) levels by nephelometry.<h4>Methods</h4>Serum samples were collected from healthy pediatric cohorts aged 32-week gestation to <18 years at 4 hospitals in Melbourne, Australia, betwee"],"journal":["Journal of the Pediatric Infectious Diseases Society"],"pagination":["piaf054"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12343097"],"repository":["biostudies-literature"],"pubmed_title":["Streptococcal Serology Reference Intervals in an Australian Pediatric Cohort."],"pmcid":["PMC12343097"],"pubmed_authors":["Bazeley S","Steer AC","Tran C","Attard C","HAPPI Kids Study Team","Tsoi SK","Lee LY","Hearps S","Osowicki J","Monagle P","Karlaftis V","Choo S","Burgess J","Challen N"],"additional_accession":[]},"is_claimable":false,"name":"Streptococcal Serology Reference Intervals in an Australian Pediatric Cohort.","description":"<h4>Background</h4>Diagnostic criteria for acute rheumatic fever and post-streptococcal glomerulonephritis, the 2 major autoimmune complications of Streptococcus pyogenes infection, include serological evidence of preceding infection. The S. pyogenes proteins, namely streptolysin O and deoxyribonuclease B, are the most widely used targets for clinical streptococcal serology. We aimed to establish age-based reference intervals (RIs) for healthy children in Victoria, Australia, to guide interpretation of anti-streptolysin O (ASO) levels measured by turbidimetry and nephelometry, and anti-deoxyribonuclease B (ADB) levels by nephelometry.<h4>Methods</h4>Serum samples were collected from healthy pediatric cohorts aged 32-week gestation to <18 years at 4 hospitals in Melbourne, Australia, betwee","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-03T21:52:34.236Z","creation":"2026-04-07T19:38:20.471Z"},"accession":"S-EPMC12343097","cross_references":{"pubmed":["40476715"],"doi":["10.1093/jpids/piaf054"]}}