{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Namazzi R"],"funding":["National Institute of Neurological Disorders and Stroke","National Institute of Diabetes and Digestive and Kidney Disease","NIDDK NIH HHS","FIC NIH HHS","NIAID NIH HHS","Fogarty International Center","NINDS NIH HHS","National Institutes of Health","Ralph W. and Grace M. Showalter","National Institutes of Allergy and Infectious Diseases","NIH HHS"],"pagination":["285-297"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12349948"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["232(2)"],"pubmed_abstract":["<h4>Background</h4>Recently, there has been an unexplained increase in the incidence of blackwater fever (BWF) in Eastern Uganda. In this study, we evaluated the association between immune complexes, glucose-6-phosphate dehydrogenase (G6PD) deficiency, and the occurrence and recurrence of BWF in children with severe malaria (SM).<h4>Methods</h4>Between 2014 and 2017, children aged 6 months to <4 years hospitalized with SM and community children (CC) were recruited at 2 hospitals in Central and Eastern Uganda. We measured serum circulating immune complexes (cIC) and their relationship to SM complications and postdischarge outcomes, and evaluated effect mediation through G6PD deficiency.<h4>Results</h4>In total, 557 children with SM and 101 CC were enrolled. The mean age was 2.1 years. Child"],"journal":["The Journal of infectious diseases"],"pubmed_title":["Circulating Immune Complexes and Glucose-6-Phosphate Dehydrogenase Deficiency Predict Recurrent Blackwater Fever in Ugandan Children With Severe Malaria."],"pmcid":["PMC12349948"],"funding_grant_id":["R21AI151349","T32DK120524","R21 AI151349","D43 TW010928","R01 NS055349","T32 DK120524","R01NS055349"],"pubmed_authors":["Goings MG","Conroy AL","Liepmann C","Kazinga C","Opoka RO","Abreu M","Mellencamp KA","Datta D","Rodriguez A","Ware RE","Schwantes-An TH","John CC","Sherman J","Lima-Cooper G","Namazzi R","Lacerda M"],"additional_accession":[]},"is_claimable":false,"name":"Circulating Immune Complexes and Glucose-6-Phosphate Dehydrogenase Deficiency Predict Recurrent Blackwater Fever in Ugandan Children With Severe Malaria.","description":"<h4>Background</h4>Recently, there has been an unexplained increase in the incidence of blackwater fever (BWF) in Eastern Uganda. In this study, we evaluated the association between immune complexes, glucose-6-phosphate dehydrogenase (G6PD) deficiency, and the occurrence and recurrence of BWF in children with severe malaria (SM).<h4>Methods</h4>Between 2014 and 2017, children aged 6 months to <4 years hospitalized with SM and community children (CC) were recruited at 2 hospitals in Central and Eastern Uganda. We measured serum circulating immune complexes (cIC) and their relationship to SM complications and postdischarge outcomes, and evaluated effect mediation through G6PD deficiency.<h4>Results</h4>In total, 557 children with SM and 101 CC were enrolled. The mean age was 2.1 years. Child","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-10T04:53:33.556Z","creation":"2026-04-08T01:32:28.064Z"},"accession":"S-EPMC12349948","cross_references":{"pubmed":["39208451"],"doi":["10.1093/infdis/jiae431"]}}