{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Russell CD"],"funding":["UK Research and Innovation/Medical Research Council (MRC)","Edinburgh Clinical Academic Track/Wellcome Trust PhD Training Fellowship","the SHIELD consortium \"Optimising Innate Host Defence to Combat Antimicrobial Resistance\"","the SHIELD consortium “Optimising Innate Host Defence to Combat Antimicrobial Resistance”","Wellcome Trust","Academy of Medical Sciences","UK Research and Innovation/Medical Research Council"],"pagination":["e290-e300"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12349957"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["232(2)"],"pubmed_abstract":["Background
Staphylococcus aureus infections are frequently complicated by metastatic foci, recurrence, and death. Antimicrobial resistance and intracellular bacterial persistence limit the effectiveness of conventional antimicrobials. Host-directed therapies could improve outcomes, but the interpretive complexity of pathogen-host interactions impedes identification of critical responses suitable for therapeutic targeting. To address this, we performed a meta-analysis of genome-scale studies aiming to prioritize host responses to S aureus.Methods
Lists of genes associated with host responses to S aureus were retrieved from systematically identified genome-scale studies, then integrated using the meta-analysis by information content (MAIC) algorithm. This generated a single a"],"journal":["The Journal of infectious diseases"],"pubmed_title":["Genome-Scale Meta-analysis of Host Responses to Staphylococcus aureus Identifies Pathways for Host-Directed Therapeutic Targeting."],"pmcid":["PMC12349957"],"funding_grant_id":["MR/NO2995X/1","SGL032\\1020","211496/Z/18/Z","214178/Z/18/Z","MR/Y013131/1)"],"pubmed_authors":["Baillie JK","Dockrell DH","Russell CD","Goeldner-Thompson S","Wang B","Millar JE","Clohisey Hendry S","Swets M","Fitzgerald JR","Smith E","Parkinson N"],"additional_accession":[]},"is_claimable":false,"name":"Genome-Scale Meta-analysis of Host Responses to Staphylococcus aureus Identifies Pathways for Host-Directed Therapeutic Targeting.","description":"Background
Staphylococcus aureus infections are frequently complicated by metastatic foci, recurrence, and death. Antimicrobial resistance and intracellular bacterial persistence limit the effectiveness of conventional antimicrobials. Host-directed therapies could improve outcomes, but the interpretive complexity of pathogen-host interactions impedes identification of critical responses suitable for therapeutic targeting. To address this, we performed a meta-analysis of genome-scale studies aiming to prioritize host responses to S aureus.Methods
Lists of genes associated with host responses to S aureus were retrieved from systematically identified genome-scale studies, then integrated using the meta-analysis by information content (MAIC) algorithm. This generated a single a","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-01T21:04:24.912Z","creation":"2026-04-07T17:16:08.849Z"},"accession":"S-EPMC12349957","cross_references":{"pubmed":["40447280"],"doi":["10.1093/infdis/jiaf290"]}}