biostudies-literatureRussell CDUK Research and Innovation/Medical Research Council (MRC)Edinburgh Clinical Academic Track/Wellcome Trust PhD Training Fellowshipthe SHIELD consortium "Optimising Innate Host Defence to Combat Antimicrobial Resistance"the SHIELD consortium “Optimising Innate Host Defence to Combat Antimicrobial Resistance”Wellcome TrustAcademy of Medical SciencesUK Research and Innovation/Medical Research Councile290-e300https://www.ebi.ac.uk/biostudies/studies/S-EPMC12349957biostudies-literatureUnknown232(2)<h4>Background</h4>Staphylococcus aureus infections are frequently complicated by metastatic foci, recurrence, and death. Antimicrobial resistance and intracellular bacterial persistence limit the effectiveness of conventional antimicrobials. Host-directed therapies could improve outcomes, but the interpretive complexity of pathogen-host interactions impedes identification of critical responses suitable for therapeutic targeting. To address this, we performed a meta-analysis of genome-scale studies aiming to prioritize host responses to S aureus.<h4>Methods</h4>Lists of genes associated with host responses to S aureus were retrieved from systematically identified genome-scale studies, then integrated using the meta-analysis by information content (MAIC) algorithm. This generated a single aThe Journal of infectious diseasesGenome-Scale Meta-analysis of Host Responses to Staphylococcus aureus Identifies Pathways for Host-Directed Therapeutic Targeting.PMC12349957MR/NO2995X/1SGL032\1020211496/Z/18/Z214178/Z/18/ZMR/Y013131/1)Baillie JKDockrell DHRussell CDGoeldner-Thompson SWang BMillar JEClohisey Hendry SSwets MFitzgerald JRSmith EParkinson NfalseGenome-Scale Meta-analysis of Host Responses to Staphylococcus aureus Identifies Pathways for Host-Directed Therapeutic Targeting.<h4>Background</h4>Staphylococcus aureus infections are frequently complicated by metastatic foci, recurrence, and death. Antimicrobial resistance and intracellular bacterial persistence limit the effectiveness of conventional antimicrobials. Host-directed therapies could improve outcomes, but the interpretive complexity of pathogen-host interactions impedes identification of critical responses suitable for therapeutic targeting. To address this, we performed a meta-analysis of genome-scale studies aiming to prioritize host responses to S aureus.<h4>Methods</h4>Lists of genes associated with host responses to S aureus were retrieved from systematically identified genome-scale studies, then integrated using the meta-analysis by information content (MAIC) algorithm. This generated a single a2025-01-01T00:00:00Z2025 Aug2026-05-01T21:04:24.912Z2026-04-07T17:16:08.849ZS-EPMC123499574044728010.1093/infdis/jiaf290