biostudies-literatureUnknown12Herrick AL<h4>Introduction</h4>Bovine respiratory disease (BRD) is the leading natural cause of death in cattle. It is a multifactorial disease comprised of bacterial and viral pathogens. To aid in the reduction of BRD morbidity and mortality and the selection of cattle with reduced susceptibility, the objectives of this study were to identify loci, gene sets, positional candidate and leading-edge genes associated with or enriched for BRD in pre-weaned and post-weaned Holstein calves.<h4>Methods</h4>From a single dairy, 518 pre-weaned (0-60 days old) and 2,001 post-weaned (61-421 days old) Holstein heifers were treated for BRD and served as cases. All 3,655 pre-weaned healthy control calves remained in the herd for a minimum of 60 days, and 3,210 healthy post-weaned control calves remained in the heFrontiers in veterinary science1637087https://www.ebi.ac.uk/biostudies/studies/S-EPMC12350131biostudies-literatureGenomic regions associated with bovine respiratory disease in pacific northwest Holstein cattle.PMC12350131Neibergs HLHerrick ALKiser JNWhite SNfalseGenomic regions associated with bovine respiratory disease in pacific northwest Holstein cattle.<h4>Introduction</h4>Bovine respiratory disease (BRD) is the leading natural cause of death in cattle. It is a multifactorial disease comprised of bacterial and viral pathogens. To aid in the reduction of BRD morbidity and mortality and the selection of cattle with reduced susceptibility, the objectives of this study were to identify loci, gene sets, positional candidate and leading-edge genes associated with or enriched for BRD in pre-weaned and post-weaned Holstein calves.<h4>Methods</h4>From a single dairy, 518 pre-weaned (0-60 days old) and 2,001 post-weaned (61-421 days old) Holstein heifers were treated for BRD and served as cases. All 3,655 pre-weaned healthy control calves remained in the herd for a minimum of 60 days, and 3,210 healthy post-weaned control calves remained in the he2025-01-01T00:00:00Z20252026-04-18T13:05:53.224Z2026-04-07T14:36:02.254ZS-EPMC123501314082265010.3389/fvets.2025.1637087