{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(3)"],"submitter":["Falck AL"],"pubmed_abstract":["<h4>Background</h4>Client-owned dogs presenting clinically with intervertebral disc disease (IVDD) are a potential comparative animal model to help advance the understanding of disc degeneration and its treatment. To utilize dog patients as a model, noninvasive imaging techniques are needed that can characterize subtle and progressive changes in disc health in longitudinal and treatment efficacy studies. The purpose of this study was to assess the sensitivity of quantitative MRI techniques in detecting disc degeneration in client-owned, nonchondrodystrophic-breed dogs.<h4>Methods</h4>Thoracolumbar vertebral columns from the donated bodies of 15 dogs without a history of IVDD were imaged at 3T MRI. Quantitative MRI maps (T2, T2*, T1ρ, adiabatic T1ρ, adiabatic T2ρ, and ADC) were acquired axi"],"journal":["JOR spine"],"pagination":["e70105"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12350182"],"repository":["biostudies-literature"],"pubmed_title":["Relationship Between Quantitative MRI and Radiological, Histological, and Biochemical Measures of Intervertebral Disc Health in Client-Owned, Nonchondrodystrophic-Breed Dogs."],"pmcid":["PMC12350182"],"pubmed_authors":["Rendahl A","McDermott K","Ober CP","Buko EO","Falck AL","Chase KL","Pendleton D","Kim O","Ellingson AM","Parvaze SP","Armstrong AR","Arnold SA","Johnson CP","Bradley EW"],"additional_accession":[]},"is_claimable":false,"name":"Relationship Between Quantitative MRI and Radiological, Histological, and Biochemical Measures of Intervertebral Disc Health in Client-Owned, Nonchondrodystrophic-Breed Dogs.","description":"<h4>Background</h4>Client-owned dogs presenting clinically with intervertebral disc disease (IVDD) are a potential comparative animal model to help advance the understanding of disc degeneration and its treatment. To utilize dog patients as a model, noninvasive imaging techniques are needed that can characterize subtle and progressive changes in disc health in longitudinal and treatment efficacy studies. The purpose of this study was to assess the sensitivity of quantitative MRI techniques in detecting disc degeneration in client-owned, nonchondrodystrophic-breed dogs.<h4>Methods</h4>Thoracolumbar vertebral columns from the donated bodies of 15 dogs without a history of IVDD were imaged at 3T MRI. Quantitative MRI maps (T2, T2*, T1ρ, adiabatic T1ρ, adiabatic T2ρ, and ADC) were acquired axi","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-02T02:45:45.283Z","creation":"2026-04-07T17:32:45.081Z"},"accession":"S-EPMC12350182","cross_references":{"pubmed":["40821359"],"doi":["10.1002/jsp2.70105"]}}