biostudies-literatureTsilochristou OAsthma UKFood Standards AgencyFood Allergy Research &amp; EducationNIAID NIH HHSNational Institutes of HealthClemens von Pirquet FoundationNIHNIAIDNational Institute of Allergy and Infectious DiseasesNational Peanut BoardBiomedical Research CentreUK Department of HealthMedical Research CouncilNational Institute for Health Research (NIHR)494-503https://www.ebi.ac.uk/biostudies/studies/S-EPMC12351383biostudies-literatureUnknown144(2)<h4>Background</h4>Staphylococcus aureus has been implicated in the pathophysiology of eczema, allergic rhinitis, asthma, and food allergy. S aureus is a marker of more severe eczema, which is a risk factor for food sensitization/allergy. Therefore it might be that the association between S aureus and food allergy in eczematous patients is related to eczema severity.<h4>Objective</h4>We sought to investigate the association of S aureus colonization with specific IgE (sIgE) production to common food allergens and allergies in early childhood independent of eczema severity. We additionally determined the association of S aureus colonization with eczema severity and persistence.<h4>Methods</h4>In Learning Early About Peanut Allergy (LEAP) study participants eczema severity was assessed, and sThe Journal of allergy and clinical immunologyAssociation of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity.PMC12351383UM2 AI117870HHSN272200800029CUM1AI109565N01 AI015416UM1 AI109565UM2AI117870NO1-AI-15416Adam MRichards KWu CTsilochristou Odu Toit GO'Dwyer-Leeson UWitham NDeutsch GCrossley MLack GStephens AWatson FAbraham MPlaut MChan SFox ANixon ACleaver RHeath JFisher HFrancisco NDCSudra AHu JPatkunam DSayre PHLussier SWhitehouse DWester RMiller TPanza JLPlough ALawson KSever MLMason TAsare ASheridan ABasting MHersee KChani EParr AImmune Tolerance Network Learning Early About Peanut Allergy Study TeamHarland GDuncan CCockerell KBecares NBahnson HTCoverdale LOfford VWilson ARadulovic SClarke CLorenzo MGPietraszewicz EEvind JStedman CLim NRoberts GfalseAssociation of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity.<h4>Background</h4>Staphylococcus aureus has been implicated in the pathophysiology of eczema, allergic rhinitis, asthma, and food allergy. S aureus is a marker of more severe eczema, which is a risk factor for food sensitization/allergy. Therefore it might be that the association between S aureus and food allergy in eczematous patients is related to eczema severity.<h4>Objective</h4>We sought to investigate the association of S aureus colonization with specific IgE (sIgE) production to common food allergens and allergies in early childhood independent of eczema severity. We additionally determined the association of S aureus colonization with eczema severity and persistence.<h4>Methods</h4>In Learning Early About Peanut Allergy (LEAP) study participants eczema severity was assessed, and s2019-01-01T00:00:00Z2019 Aug2026-04-13T07:07:14.991Z2026-04-07T13:24:40.975ZS-EPMC123513833116003410.1016/j.jaci.2019.04.025