{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Horisberger A"],"funding":["NCATS NIH HHS","National Institutes of Health","NIAMS NIH HHS"],"pagination":["e181034"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12352894"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["135(16)"],"pubmed_abstract":["Lupus nephritis (LN) is a frequent manifestation of systemic lupus erythematosus, and fewer than half of patients achieve complete renal response with standard immunosuppressants. Identifying noninvasive, blood-based immune alterations associated with renal injury could aid therapeutic decisions. Here, we used mass cytometry immunophenotyping of peripheral blood mononuclear cells in 145 patients with biopsy-proven LN and 40 healthy controls to evaluate the heterogeneity of immune activation and identify correlates of renal parameters. Unbiased analysis identified 3 immunologically distinct groups of patients that were associated with different patterns of histopathology, renal cell infiltrates, urine proteomic profiles, and treatment response at 1 year. Patients with enriched circulating g"],"journal":["The Journal of clinical investigation"],"pubmed_title":["Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis."],"pmcid":["PMC12352894"],"funding_grant_id":["UH2 AR067689","UH2 AR067679","UL1 TR002541","UH2-AR067691","UH2 AR067694","UH2-AR067681","UH2 AR067681","and UM2- AR067678","UH2-AR067694","UH2 AR067676","UH2 AR067688","UH2 AR067677","UH2 AR067685","UH2-AR067690","UM2 AR067678","UH2-AR067677","UH2-AR067688","UH2-AR067689","UH2-AR067679","UH2 AR067690","UH2 AR067691","UH2-AR067685","UH2-AR067676"],"pubmed_authors":["Pulford J","Zhang F","Wofsy D","Davidson A","Raychaudhuri S","Guthridge J","Buyon JP","Hancock B","Payan-Schober F","Gutierrez-Arcelus M","Weisman M","Eisenhaure TM","Furie R","Berthier CC","Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network","James JA","Dall'Era M","Kalunian KC","Grossman J","Keegan J","Kretzler M","Brenner MB","Hacohen N","Ishimori M","Griffith A","McMahon MA","Diamond B","Barnas JL","Sasaki T","Howard K","Demeke DS","Clancy R","Arazi A","Belmont M","Lederer JA","Horisberger A","Apruzzese W","Preisinger K","Beuschel R","Izmirly P","Petri MA","Fava A","Hodgin JB","Rao DA","Hoover PJ","Anolik JH","Inamo J","Ghosh T","Woodle ES","Putterman C","Cao Y","Hildeman D","Murzin E","Kamen DL"],"additional_accession":[]},"is_claimable":false,"name":"Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis.","description":"Lupus nephritis (LN) is a frequent manifestation of systemic lupus erythematosus, and fewer than half of patients achieve complete renal response with standard immunosuppressants. Identifying noninvasive, blood-based immune alterations associated with renal injury could aid therapeutic decisions. Here, we used mass cytometry immunophenotyping of peripheral blood mononuclear cells in 145 patients with biopsy-proven LN and 40 healthy controls to evaluate the heterogeneity of immune activation and identify correlates of renal parameters. Unbiased analysis identified 3 immunologically distinct groups of patients that were associated with different patterns of histopathology, renal cell infiltrates, urine proteomic profiles, and treatment response at 1 year. Patients with enriched circulating g","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-29T15:28:44.456Z","creation":"2026-04-08T05:20:15.866Z"},"accession":"S-EPMC12352894","cross_references":{"pubmed":["40536813"],"doi":["10.1172/JCI181034"]}}