biostudies-literatureUnknownLatham RMNICHD NIH HHSThis study investigated associations between childhood neighborhood deprivation and adolescent mental health difficulties, and potential protective factors. Data were utilized from the Millennium Cohort Study (MCS) (born in 2000-2002; <i>N</i> = 5,422; 52% female) and the Environmental Risk (E-Risk) Longitudinal Twin Study (born in 1994-1995; <i>N</i> = 1,920; 53% female). Childhood neighborhood deprivation was measured using the Index of Multiple Deprivation between age 9 months and 14 years (MCS) and at age 12 (E-Risk). Adolescent mental health was assessed using the Strengths and Difficulties Questionnaire at age 17 (MCS) and the Diagnostic Interview Schedule conducted at age 18 with symptoms loading onto general psychopathology, internalizing and externalizing factors (E-Risk). Cross-cDevelopment and psychopathology1-15https://www.ebi.ac.uk/biostudies/studies/S-EPMC12353556biostudies-literatureUnderstanding and mitigating associations between childhood neighborhood deprivation and adolescent mental health in two UK birth cohorts.PMC12353556R01 HD077482Latham RMBlangis FArseneault LBakolis IDas-Munshi JMoreno-Agostino DPloubidis GBFisher HLfalseUnderstanding and mitigating associations between childhood neighborhood deprivation and adolescent mental health in two UK birth cohorts.This study investigated associations between childhood neighborhood deprivation and adolescent mental health difficulties, and potential protective factors. Data were utilized from the Millennium Cohort Study (MCS) (born in 2000-2002; <i>N</i> = 5,422; 52% female) and the Environmental Risk (E-Risk) Longitudinal Twin Study (born in 1994-1995; <i>N</i> = 1,920; 53% female). Childhood neighborhood deprivation was measured using the Index of Multiple Deprivation between age 9 months and 14 years (MCS) and at age 12 (E-Risk). Adolescent mental health was assessed using the Strengths and Difficulties Questionnaire at age 17 (MCS) and the Diagnostic Interview Schedule conducted at age 18 with symptoms loading onto general psychopathology, internalizing and externalizing factors (E-Risk). Cross-c2025-01-01T00:00:00Z2025 Apr2026-06-04T04:49:08.071Z2026-05-05T03:12:36.581ZS-EPMC123535564019009010.1017/s095457942500020310.1017/S0954579425000203