{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao C"],"funding":["Science and Technology Bureau of Jiangning District"],"pagination":["1549"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12354449"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Cuproptosis is a newly defined regulated cell death model and is considered as a potential approach for cancer treatment. We have previously found that cervical cancer cells have the capability of anti-ferroptosis. A recent study has reported that elesclomol (ES) is able to induce copper-dependent ferroptosis. However, its effect on cervical cancer cell ferroptosis is still unclear. In this study, we found that the expression levels of copper metabolism-related genes ATP7A and ATP7B were decreased in cervical cancer tissues. In cervical cancer cells, combined treatment of ES and Cu<sup>2+</sup> inhibited cell proliferation and promoted cell death, but did not promote cuproptosis. However, ES-Cu<sup>2+</sup> treatment led to the accumulation of cellular reactive oxygen species, increased ce"],"journal":["Discover oncology"],"pubmed_title":["Copper-overload promotes ferroptosis in cervical cancer cells by upregulating HMOX1 expression."],"pmcid":["PMC12354449"],"funding_grant_id":["2024048S"],"pubmed_authors":["Zhao C","Chen J","Lu Y","Wang T","Zhou Y","Ju R"],"additional_accession":[]},"is_claimable":false,"name":"Copper-overload promotes ferroptosis in cervical cancer cells by upregulating HMOX1 expression.","description":"Cuproptosis is a newly defined regulated cell death model and is considered as a potential approach for cancer treatment. We have previously found that cervical cancer cells have the capability of anti-ferroptosis. A recent study has reported that elesclomol (ES) is able to induce copper-dependent ferroptosis. However, its effect on cervical cancer cell ferroptosis is still unclear. In this study, we found that the expression levels of copper metabolism-related genes ATP7A and ATP7B were decreased in cervical cancer tissues. In cervical cancer cells, combined treatment of ES and Cu<sup>2+</sup> inhibited cell proliferation and promoted cell death, but did not promote cuproptosis. However, ES-Cu<sup>2+</sup> treatment led to the accumulation of cellular reactive oxygen species, increased ce","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-07-15T06:30:34.316Z","creation":"2026-06-30T03:23:06.7Z"},"accession":"S-EPMC12354449","cross_references":{"pubmed":["40810778"],"doi":["10.1007/s12672-025-03421-2"]}}