{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Xu X"],"pubmed_abstract":["The relationship between calcium oscillation and cell sensitivity is poorly understood. Calcium oscillation can occur spontaneously or be triggered upon receptor-ligand binding. The cytosolic [Ca<sup>2+</sup>] increase during calcium oscillation is initiated from Ca<sup>2+</sup> release from the intracellular stores through the phospholipase C (PLC)-derived inositol 1,4,5-trisphosphate (IP<sub>3</sub>). Here, we show that neutrophil-like HL60 cells lacking PLCγ2 (<i>plcg2<sup>kd</sup></i> ) exhibit impaired spontaneous calcium oscillation and a diminished calcium response to chemoattractant stimulation. These defects result in reduced membrane targeting of RasGAP CAPRI (calcium-promoted Ras inactivator), and subsequent elevated Ras activations and enhanced downstream signaling, including P"],"journal":["Frontiers in immunology"],"pagination":["1633390"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12354650"],"repository":["biostudies-literature"],"pubmed_title":["PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis."],"pmcid":["PMC12354650"],"pubmed_authors":["Lee A","Jin T","Kim WS","Xu X"],"additional_accession":[]},"is_claimable":false,"name":"PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis.","description":"The relationship between calcium oscillation and cell sensitivity is poorly understood. Calcium oscillation can occur spontaneously or be triggered upon receptor-ligand binding. The cytosolic [Ca<sup>2+</sup>] increase during calcium oscillation is initiated from Ca<sup>2+</sup> release from the intracellular stores through the phospholipase C (PLC)-derived inositol 1,4,5-trisphosphate (IP<sub>3</sub>). Here, we show that neutrophil-like HL60 cells lacking PLCγ2 (<i>plcg2<sup>kd</sup></i> ) exhibit impaired spontaneous calcium oscillation and a diminished calcium response to chemoattractant stimulation. These defects result in reduced membrane targeting of RasGAP CAPRI (calcium-promoted Ras inactivator), and subsequent elevated Ras activations and enhanced downstream signaling, including P","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-02T02:47:18.573Z","creation":"2026-04-07T17:34:41.812Z"},"accession":"S-EPMC12354650","cross_references":{"pubmed":["40821808"],"doi":["10.3389/fimmu.2025.1633390"]}}