{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Staehle HF"],"funding":["Deutsche Forschungsgemeinschaft (German Research Foundation)"],"pagination":["619"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12354751"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["The lysine-specific demethylase 1 (LSD1) regulates hematopoietic stem cell differentiation and has been identified as a therapeutic target in hematological disorders. LSD1 demethylates mono and dimethylated histones 3 at lysine 4 and 9. In addition, it acts as a scaffold for the formation of chromatin-modifying complexes that regulates the transcription of myeloid-lineage-specific genes in complex with GFI1, a transcriptional repressor. While both enzymatic and non-enzymatic functions of LSD1 have been well defined, the relative importance of these two functions in hematopoiesis remains incompletely understood. Here, we investigated the contribution of enzymatic and non-enzymatic functions of LSD1 to myelopoiesis. We show that myeloid differentiation is independent of the enzymatic functio"],"journal":["Cell death & disease"],"pubmed_title":["Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation."],"pmcid":["PMC12354751"],"funding_grant_id":["RI 1283/15-1/2","MA 7792/1-1/2","PE 3217/4-1","Pa 611/9-1/2","Ju 31041/1-1","Pa 611/11-1","JU 3104/2-1","Br 3535/2-1/2","Pa 611/5-3"],"pubmed_authors":["Muller JM","Imbusch CD","Staehle AM","Attia A","Zell F","Pozdnyakova O","Mallm JP","Pahl HL","Schule R","Metzger E","Staehle HF","Eble P","Rippe K","Feuerbach L","Muller A","Brors B","Jutzi JS","Koellerer C","Schulze J","Perner F"],"additional_accession":[]},"is_claimable":false,"name":"Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation.","description":"The lysine-specific demethylase 1 (LSD1) regulates hematopoietic stem cell differentiation and has been identified as a therapeutic target in hematological disorders. LSD1 demethylates mono and dimethylated histones 3 at lysine 4 and 9. In addition, it acts as a scaffold for the formation of chromatin-modifying complexes that regulates the transcription of myeloid-lineage-specific genes in complex with GFI1, a transcriptional repressor. While both enzymatic and non-enzymatic functions of LSD1 have been well defined, the relative importance of these two functions in hematopoiesis remains incompletely understood. Here, we investigated the contribution of enzymatic and non-enzymatic functions of LSD1 to myelopoiesis. We show that myeloid differentiation is independent of the enzymatic functio","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-07-15T14:11:33.705Z","creation":"2026-07-06T03:08:40.917Z"},"accession":"S-EPMC12354751","cross_references":{"pubmed":["40813574"],"doi":["10.1038/s41419-025-07951-z"]}}