biostudies-literatureParker DAU.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)NCATS NIH HHSU.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS)NIMH NIH HHS281https://www.ebi.ac.uk/biostudies/studies/S-EPMC12354876biostudies-literatureUnknown15(1)Idiopathic psychosis shows considerable biological heterogeneity across cases. The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) used psychosis-relevant biomarkers to identify psychosis Biotypes, which will aid etiological and targeted treatment investigations. Here, our previous approach (Clementz et al. 2022) is updated, which supports the development of an efficient psychosis Biotype diagnostic procedure called ADEPT. Psychosis probands (n = 1907), their first-degree biological relatives (n = 705), and healthy participants (n = 895) completed a biomarker battery composed of cognitive performance, saccades, and auditory EEG/ERP measurements. EEG and ERP quantifications were modified from previous Biotypes iterations. Multivariate integration using multiple approachesTranslational psychiatryDifferentiating biomarker features and familial characteristics of B-SNIP psychosis Biotypes.PMC12354876R01 MH078113MH127174MH077945TL1TR002382UL1 TR002378MH096942UL1TR002378MH096900MH103368MH127179MH127158MH103366R01 MH096900TL1 TR002382MH124813R01 MH096942R01 MH124813MH077851R01 MH077945MH127162R01 MH124807R01 MH077851R01 MH124806R01 MH124803R01 MH124804R21 MH126398R01 MH127162MH096913MH096957MH126398R01 MH127158R01 MH127179MH124803R01 MH096913R01 MH103368MH124802R01 MH096957MH124804MH124807MH124806R01 MH127174MH078113R01 MH124802R01 MH103366Pearlson GDClementz BAKeshavan MSHill SKKeedy SKIvleva EIMcDowell JETamminga CATrotti RLGershon ESHuang LYParker DASauer KSweeney JAfalseDifferentiating biomarker features and familial characteristics of B-SNIP psychosis Biotypes.Idiopathic psychosis shows considerable biological heterogeneity across cases. The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) used psychosis-relevant biomarkers to identify psychosis Biotypes, which will aid etiological and targeted treatment investigations. Here, our previous approach (Clementz et al. 2022) is updated, which supports the development of an efficient psychosis Biotype diagnostic procedure called ADEPT. Psychosis probands (n = 1907), their first-degree biological relatives (n = 705), and healthy participants (n = 895) completed a biomarker battery composed of cognitive performance, saccades, and auditory EEG/ERP measurements. EEG and ERP quantifications were modified from previous Biotypes iterations. Multivariate integration using multiple approaches2025-01-01T00:00:00Z2025 Aug2026-04-16T15:08:57.891Z2026-04-07T14:12:22.702ZS-EPMC123548764081386510.1038/s41398-025-03501-5