biostudies-literatureAhmad SEuropean Research Council101468https://www.ebi.ac.uk/biostudies/studies/S-EPMC12355076biostudies-literatureUnknown7(9)<h4>Background & aims</h4>A quarter of the world population is estimated to have metabolic dysfunction-associated steatotic liver disease. Here, we aim to understand the impact of liver trait-associated genetic variants on fat content and tissue volume across organs and body compartments and on a large set of biomarkers.<h4>Methods</h4>Genome-wide association analyses were performed on liver fat and liver volume estimated with magnetic resonance imaging in up to 27,243 unrelated European participants from the UK Biobank. Identified variants were assessed for associations with fat fraction and tissue volume in >2 million 'Imiomics' image elements in 22,261 individuals and with circulating biomarkers in 310,224 individuals.<h4>Results</h4>We confirmed four liver fat and nine liver volume preJHEP reports : innovation in hepatologyImpact of genetic variants linked to liver fat and liver volume on MRI-mapped body composition.PMC12355076801965Hammar URomero-Lado MJAhmad SKennedy BKullberg JCensin JCMenzel UMartinez Mora AAhmad NLangner TKilpelainen TOSayols-Baixeras SFall TLind LCarrasquilla GDNguyen DDekkers KFMalmberg FAhlstrom HEriksson JWStrand RfalseImpact of genetic variants linked to liver fat and liver volume on MRI-mapped body composition.<h4>Background & aims</h4>A quarter of the world population is estimated to have metabolic dysfunction-associated steatotic liver disease. Here, we aim to understand the impact of liver trait-associated genetic variants on fat content and tissue volume across organs and body compartments and on a large set of biomarkers.<h4>Methods</h4>Genome-wide association analyses were performed on liver fat and liver volume estimated with magnetic resonance imaging in up to 27,243 unrelated European participants from the UK Biobank. Identified variants were assessed for associations with fat fraction and tissue volume in >2 million 'Imiomics' image elements in 22,261 individuals and with circulating biomarkers in 310,224 individuals.<h4>Results</h4>We confirmed four liver fat and nine liver volume pre2025-01-01T00:00:00Z2025 Sep2026-05-29T17:56:18.619Z2026-05-18T03:07:27.387ZS-EPMC123550764082317510.1016/j.jhepr.2025.101468