{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(31)"],"submitter":["Ponpao N"],"pubmed_abstract":["A green, convenient, and metal-free methodology for synthesizing primary aniline-based indolylmethanes has been developed through a sequential one-pot, three-component aza-Friedel-Crafts reaction. This approach employs a wide range of commercially available aldehydes, primary anilines, and indoles, catalyzed by a Brønsted acidic ionic liquid in an aqueous medium. A variety of desirable products were obtained in high yields (up to 98%). The process was successfully demonstrated on a gram scale, confirming its scalability and reproducibility while maintaining high yields. Additionally, the catalyst exhibited remarkable recyclability, retaining high catalytic efficiency over three cycles without a significant loss of activity."],"journal":["ACS omega"],"pagination":["34951-34963"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12355243"],"repository":["biostudies-literature"],"pubmed_title":["Green Synthesis of Primary Aniline-Based Indolylmethanes via One-Pot Aza-Friedel-Crafts Reaction Catalyzed by Bronsted Acidic Ionic Liquid in Aqueous Media."],"pmcid":["PMC12355243"],"pubmed_authors":["Ponpao N","Sirion U","Suksai C","Masnguluem P","Jaratjaroonphong J","Trakulsujaritchok T","Senapak W"],"additional_accession":[]},"is_claimable":false,"name":"Green Synthesis of Primary Aniline-Based Indolylmethanes via One-Pot Aza-Friedel-Crafts Reaction Catalyzed by Bronsted Acidic Ionic Liquid in Aqueous Media.","description":"A green, convenient, and metal-free methodology for synthesizing primary aniline-based indolylmethanes has been developed through a sequential one-pot, three-component aza-Friedel-Crafts reaction. This approach employs a wide range of commercially available aldehydes, primary anilines, and indoles, catalyzed by a Brønsted acidic ionic liquid in an aqueous medium. A variety of desirable products were obtained in high yields (up to 98%). The process was successfully demonstrated on a gram scale, confirming its scalability and reproducibility while maintaining high yields. Additionally, the catalyst exhibited remarkable recyclability, retaining high catalytic efficiency over three cycles without a significant loss of activity.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-10T04:15:02.288Z","creation":"2026-04-08T01:29:36.678Z"},"accession":"S-EPMC12355243","cross_references":{"pubmed":["40821540"],"doi":["10.1021/acsomega.5c04294"]}}