biostudies-literatureUnknown10(31)Ponpao NA green, convenient, and metal-free methodology for synthesizing primary aniline-based indolylmethanes has been developed through a sequential one-pot, three-component aza-Friedel-Crafts reaction. This approach employs a wide range of commercially available aldehydes, primary anilines, and indoles, catalyzed by a Brønsted acidic ionic liquid in an aqueous medium. A variety of desirable products were obtained in high yields (up to 98%). The process was successfully demonstrated on a gram scale, confirming its scalability and reproducibility while maintaining high yields. Additionally, the catalyst exhibited remarkable recyclability, retaining high catalytic efficiency over three cycles without a significant loss of activity.ACS omega34951-34963https://www.ebi.ac.uk/biostudies/studies/S-EPMC12355243biostudies-literatureGreen Synthesis of Primary Aniline-Based Indolylmethanes via One-Pot Aza-Friedel-Crafts Reaction Catalyzed by Bronsted Acidic Ionic Liquid in Aqueous Media.PMC12355243Ponpao NSirion USuksai CMasnguluem PJaratjaroonphong JTrakulsujaritchok TSenapak WfalseGreen Synthesis of Primary Aniline-Based Indolylmethanes via One-Pot Aza-Friedel-Crafts Reaction Catalyzed by Bronsted Acidic Ionic Liquid in Aqueous Media.A green, convenient, and metal-free methodology for synthesizing primary aniline-based indolylmethanes has been developed through a sequential one-pot, three-component aza-Friedel-Crafts reaction. This approach employs a wide range of commercially available aldehydes, primary anilines, and indoles, catalyzed by a Brønsted acidic ionic liquid in an aqueous medium. A variety of desirable products were obtained in high yields (up to 98%). The process was successfully demonstrated on a gram scale, confirming its scalability and reproducibility while maintaining high yields. Additionally, the catalyst exhibited remarkable recyclability, retaining high catalytic efficiency over three cycles without a significant loss of activity.2025-01-01T00:00:00Z2025 Aug2026-05-10T04:15:02.288Z2026-04-08T01:29:36.678ZS-EPMC123552434082154010.1021/acsomega.5c04294