biostudies-literatureUnknown87Wang L<h4>Background</h4>The optimal management strategy for patients undergoing veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for cardiogenic shock (CS) remains uncertain. To evaluate the impact of "bundled" physiologic targets on outcomes in VA-ECMO patients.<h4>Methods</h4>This retrospective cohort study analyzed data from the Extracorporeal Life Support Organization (ELSO) registry, including adult patients receiving VA-ECMO for CS between 2013 and 2022. Patients were grouped by whether they received the full set of bundle components within the first 24 h. The bundle included mean arterial pressure > 65 mmHg, PaO₂ 60-150 mmHg, relative change in PaCO₂ [RelΔCO₂] > -50% (RelΔCO₂ = [(PaCO_2-24hours-PaCO_2-baseline)/PaEClinicalMedicine103423https://www.ebi.ac.uk/biostudies/studies/S-EPMC12355413biostudies-literatureA simple VA-ECMO bundle in adult patients with cardiogenic shock: an analysis of ELSO registry.PMC12355413Fan ETonna JELi CHao XDu ZWang HWang YHou XRycus PTWang KYang FWang LfalseA simple VA-ECMO bundle in adult patients with cardiogenic shock: an analysis of ELSO registry.<h4>Background</h4>The optimal management strategy for patients undergoing veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for cardiogenic shock (CS) remains uncertain. To evaluate the impact of "bundled" physiologic targets on outcomes in VA-ECMO patients.<h4>Methods</h4>This retrospective cohort study analyzed data from the Extracorporeal Life Support Organization (ELSO) registry, including adult patients receiving VA-ECMO for CS between 2013 and 2022. Patients were grouped by whether they received the full set of bundle components within the first 24 h. The bundle included mean arterial pressure > 65 mmHg, PaO₂ 60-150 mmHg, relative change in PaCO₂ [RelΔCO₂] > -50% (RelΔCO₂ = [(PaCO_2-24hours-PaCO_2-baseline)/Pa2025-01-01T00:00:00Z2025 Sep2026-05-04T16:41:30.717Z2026-04-25T03:11:10.015ZS-EPMC123554134082350110.1016/j.eclinm.2025.103423