{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(31)"],"submitter":["Zheng R"],"pubmed_abstract":["<i>Eruca sativa</i> (rocket salad; arugula) is a well-known edible plant commonly used in salads and as a topping for pizza and pasta. In this study, one new cyclic thiocarbamate (<b>1</b>) and four new kaempferol glycosides (<b>2</b>-<b>5</b>), along with 15 known compounds (<b>6</b>-<b>20</b>), were isolated from leaves of <i>E. sativa</i> using chromatographic methods. The structures of all compounds were elucidated based on their HR-ESI-MS, <sup>1</sup>H and <sup>13</sup>C NMR, and 2D NMR data. All isolates were evaluated for their cardioprotective and antiplatelet activities. Among them, compound <b>2</b> exhibited the most potent antioxidant activity in a DPPH assay. Further investigation revealed that compound <b>2</b> significantly reduced cellular ROS levels in H9c2 cardiomyocytes"],"journal":["ACS omega"],"pagination":["35241-35251"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12355429"],"repository":["biostudies-literature"],"pubmed_title":["Chemical Constituents from the Leaves of &lt;i&gt;Eruca sativa&lt;/i&gt; (Rocket Salad) Exhibiting Dual Cardioprotective and Antiplatelet Activities."],"pmcid":["PMC12355429"],"pubmed_authors":["Chang TS","Park JW","Chin YW","Zheng R","Oh EB"],"additional_accession":[]},"is_claimable":false,"name":"Chemical Constituents from the Leaves of &lt;i&gt;Eruca sativa&lt;/i&gt; (Rocket Salad) Exhibiting Dual Cardioprotective and Antiplatelet Activities.","description":"<i>Eruca sativa</i> (rocket salad; arugula) is a well-known edible plant commonly used in salads and as a topping for pizza and pasta. In this study, one new cyclic thiocarbamate (<b>1</b>) and four new kaempferol glycosides (<b>2</b>-<b>5</b>), along with 15 known compounds (<b>6</b>-<b>20</b>), were isolated from leaves of <i>E. sativa</i> using chromatographic methods. The structures of all compounds were elucidated based on their HR-ESI-MS, <sup>1</sup>H and <sup>13</sup>C NMR, and 2D NMR data. All isolates were evaluated for their cardioprotective and antiplatelet activities. Among them, compound <b>2</b> exhibited the most potent antioxidant activity in a DPPH assay. Further investigation revealed that compound <b>2</b> significantly reduced cellular ROS levels in H9c2 cardiomyocytes","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-10T04:17:00.541Z","creation":"2026-04-08T01:27:44.141Z"},"accession":"S-EPMC12355429","cross_references":{"pubmed":["40821514"],"doi":["10.1021/acsomega.5c05585"]}}