{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu S"],"funding":["financial grants from the Natural Science Foundation of Fujian Province"],"pagination":["285"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12356972"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["Rho GTPase-activating protein 4 (ARHGAP4) is implicated in poor prognosis across multiple malignancies. However, its role in driving stemness in colorectal cancer (CRC) remains unclear. In this study, we demonstrate that ARHGAP4 drives CRC stemness through a positive feedback loop involving MYH9/β-catenin/c-Jun, as validated by integrated bioinformatics analysis, in vitro and in vivo tumor stemness assays, co-immunoprecipitation, chromatin immunoprecipitation, and fluorescence recovery after photobleaching. These findings identify ARHGAP4 as a promising therapeutic target in CRC, particularly for addressing cancer stem cells (CSCs)."],"journal":["NPJ precision oncology"],"pubmed_title":["ARHGAP4/MYH9/β-catenin/c-Jun positive feedback loop promotes colorectal cancer stemness."],"pmcid":["PMC12356972"],"funding_grant_id":["2022J011024"],"pubmed_authors":["Li W","Mi Y","Lin S","Tan S","Chen Y","Liu S","Yang C"],"additional_accession":[]},"is_claimable":false,"name":"ARHGAP4/MYH9/β-catenin/c-Jun positive feedback loop promotes colorectal cancer stemness.","description":"Rho GTPase-activating protein 4 (ARHGAP4) is implicated in poor prognosis across multiple malignancies. However, its role in driving stemness in colorectal cancer (CRC) remains unclear. In this study, we demonstrate that ARHGAP4 drives CRC stemness through a positive feedback loop involving MYH9/β-catenin/c-Jun, as validated by integrated bioinformatics analysis, in vitro and in vivo tumor stemness assays, co-immunoprecipitation, chromatin immunoprecipitation, and fluorescence recovery after photobleaching. These findings identify ARHGAP4 as a promising therapeutic target in CRC, particularly for addressing cancer stem cells (CSCs).","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-07-01T03:12:14.841Z","creation":"2026-07-01T03:07:13.453Z"},"accession":"S-EPMC12356972","cross_references":{"pubmed":["40817404"],"doi":["10.1038/s41698-025-01022-4"]}}