{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Barrionuevo PA"],"pubmed_abstract":["Melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) play a critical role in regulating physiological and behavioral responses to light. However, little is known about how melanopsin and ipRGC signals are shaped by the statistical properties of real-world environments. Here, we analyzed the statistics of melanopsin, ipRGC codification of extrinsic and intrinsic photoresponses, and luminance using hyperspectral images of natural and human-made scenes under daylight illumination. The statistics were obtained by modeling human retinal receptive fields from current knowledge about ipRGC anatomy and physiology. Our findings reveal that human-made environments exhibit significantly higher melanopsin, luminance, and ipRGC excitations compared to natural environments."],"journal":["Scientific reports"],"pagination":["29965"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12356983"],"repository":["biostudies-literature"],"pubmed_title":["Melanopsin-mediated image statistics from natural and human-made environments."],"pmcid":["PMC12356983"],"pubmed_authors":["Barrionuevo PA","Diaz-Barrancas F"],"additional_accession":[]},"is_claimable":false,"name":"Melanopsin-mediated image statistics from natural and human-made environments.","description":"Melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) play a critical role in regulating physiological and behavioral responses to light. However, little is known about how melanopsin and ipRGC signals are shaped by the statistical properties of real-world environments. Here, we analyzed the statistics of melanopsin, ipRGC codification of extrinsic and intrinsic photoresponses, and luminance using hyperspectral images of natural and human-made scenes under daylight illumination. The statistics were obtained by modeling human retinal receptive fields from current knowledge about ipRGC anatomy and physiology. Our findings reveal that human-made environments exhibit significantly higher melanopsin, luminance, and ipRGC excitations compared to natural environments.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-30T15:45:40.512Z","creation":"2026-04-07T16:08:30.847Z"},"accession":"S-EPMC12356983","cross_references":{"pubmed":["40817392"],"doi":["10.1038/s41598-025-15981-y"]}}