{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen L"],"funding":["Scientific Research Foundation of Wuhan Union Hospital","National Key R&D Program of China","National Natural Science Foundation of China","National Key Research and Development Program of China"],"pagination":["e70447"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12356993"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(8)"],"pubmed_abstract":["<h4>Background</h4>Fucosyltransferase 2 (FUT2)-dependent fucosylation of intestinal epithelial cells is vital for preserving gut barrier integrity and microbial balance. Nevertheless, its precise involvement in alcohol-associated liver disease has yet to be fully elucidated.<h4>Methods</h4>We generated mice with intestinal epithelial cell-specific Fut2 knockout (Fut2<sup>△IEC</sup>) and established a chronic-binge alcohol model. 16S rRNA sequencing and metabolomics analysis were used to reveal differences in the composition and function of faecal bacteria.<h4>Results</h4>The loss of intestinal epithelial Fut2 exacerbates alcohol-related hepatic oxidative stress damage, and this effect is dependent on gut bacteria. A marked decrease in the abundance of bacteria carrying nicotinamidase (PncA"],"journal":["Clinical and translational medicine"],"pubmed_title":["Intestinal Fut2 deficiency exacerbated alcohol-related liver disease by disrupting nicotinamide metabolism."],"pmcid":["PMC12356993"],"funding_grant_id":["2023XHYN019","82000561","2022YFA1305600","81974062","82400652","82274314","82100375","82470584"],"pubmed_authors":["Shang L","Wang S","Chen L","Chu H","Gao W","Yuan H","Hou X","Yang S","Yin Z"],"additional_accession":[]},"is_claimable":false,"name":"Intestinal Fut2 deficiency exacerbated alcohol-related liver disease by disrupting nicotinamide metabolism.","description":"<h4>Background</h4>Fucosyltransferase 2 (FUT2)-dependent fucosylation of intestinal epithelial cells is vital for preserving gut barrier integrity and microbial balance. Nevertheless, its precise involvement in alcohol-associated liver disease has yet to be fully elucidated.<h4>Methods</h4>We generated mice with intestinal epithelial cell-specific Fut2 knockout (Fut2<sup>△IEC</sup>) and established a chronic-binge alcohol model. 16S rRNA sequencing and metabolomics analysis were used to reveal differences in the composition and function of faecal bacteria.<h4>Results</h4>The loss of intestinal epithelial Fut2 exacerbates alcohol-related hepatic oxidative stress damage, and this effect is dependent on gut bacteria. A marked decrease in the abundance of bacteria carrying nicotinamidase (PncA","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-01T18:43:32.261Z","creation":"2026-04-07T17:09:19.828Z"},"accession":"S-EPMC12356993","cross_references":{"pubmed":["40817598"],"doi":["10.1002/ctm2.70447"]}}