biostudies-literatureUnknown18Liang H<h4>Background</h4>Ulcerative colitis (UC), a chronic immune-mediated colon inflammation, impacts patients' quality of life. Immunosuppressive-treated UC patients are prone to opportunistic infections like cytomegalovirus (CMV) infection, which exacerbates UC, causes steroid resistance, and elevates surgery and mortality risks. Identifying CMV colitis from UC exacerbation is difficult due to overlapping symptoms and low biopsy detection rates.<h4>Objectives</h4>To develop an artificial intelligence (AI)-based multimodal model for early identification of UC with concomitant CMV colitis.<h4>Design</h4>This was a retrospective diagnostic study.<h4>Methods</h4>A total of 174 moderate to severe UC patients (87 with CMV colitis) from 2015 to 2023 in Peking Union Medical College Hospital were enrTherapeutic advances in gastroenterology17562848251364194https://www.ebi.ac.uk/biostudies/studies/S-EPMC12357019biostudies-literatureArtificial intelligence-based multimodal model for the identification of ulcerative colitis with concomitant cytomegalovirus colitis.PMC12357019Yang HWu JLiang HFu XTian YHan WGuo CRuan GWang YShi JBai XSun YfalseArtificial intelligence-based multimodal model for the identification of ulcerative colitis with concomitant cytomegalovirus colitis.<h4>Background</h4>Ulcerative colitis (UC), a chronic immune-mediated colon inflammation, impacts patients' quality of life. Immunosuppressive-treated UC patients are prone to opportunistic infections like cytomegalovirus (CMV) infection, which exacerbates UC, causes steroid resistance, and elevates surgery and mortality risks. Identifying CMV colitis from UC exacerbation is difficult due to overlapping symptoms and low biopsy detection rates.<h4>Objectives</h4>To develop an artificial intelligence (AI)-based multimodal model for early identification of UC with concomitant CMV colitis.<h4>Design</h4>This was a retrospective diagnostic study.<h4>Methods</h4>A total of 174 moderate to severe UC patients (87 with CMV colitis) from 2015 to 2023 in Peking Union Medical College Hospital were enr2025-01-01T00:00:00Z20252026-05-04T18:52:22.855Z2026-04-24T03:08:15.092ZS-EPMC123570194082173710.1177/17562848251364194