biostudies-literatureUnknown16Rizvi M<h4>Objectives</h4>Rising antimicrobial resistance (AMR) in <i>Escherichia coli</i> urinary tract infections (UTI) poses a global challenge. Evidence-based treatment of cystitis requires local resistance data. The DASH to Protect Antibiotics (https://dashuti.com/), a multi-regional group, supports centers in generating and sharing focused antibiograms to guide stewardship in community UTIs. This multi-country study aimed to describe antimicrobial susceptibility patterns of community-acquired <i>E. coli</i> isolates in low, middle, and high-income countries (LMICs and HICs).<h4>Methods</h4>The study was conducted in 37 representative centers across 13 countries in Asia (Middle East and Indian Subcontinent), Africa, Europe, and North America. A rigorous comparative analysis of the antimicrobIJID regions100706https://www.ebi.ac.uk/biostudies/studies/S-EPMC12357049biostudies-literatureMapping antimicrobial susceptibility of community-acquired uropathogenic Escherichia coli across low, middle and high-income countries highlights significant differences: insights for empiric treatment.PMC12357049Al-Busaidi IKHRiyami NMAAAl-Abri SSIshchenko ONasrin MAbolghasemi SMamari AASiddiqui AHBusaidi NHAAAlmahrouqi AShizawi NAHughes SMasters KHassan AAtif SMPrincess IAl-Jardani AKapoor GSingh SSami HAhanjan MIskandar KJabri ZAGul AMaqbali SAWali WJohn KHSMaani AAYaqoob SShaukat ASoman RAl Zadjali RGhafur AAbri RAKindi NAMuharrmi ZAJena PPBalkhair AShidhani ASHAMalhotra STaneja NEltahir HAKhan SHPatwardhan VVKhandait MKhan WChoudhury JLuthfee NMPoojary AYazidi LAAlRisi ESASardana RMufarji AATamtami NKALangford BSubhi MSASiyabi NKAShaukat SStepanskyi DSidairi HASengupta MKanungo RAlkharusi ANSLawati HJABanerjee SRashdi AADougnon VSingh APravalina RKapoor PGhoshal UGoel NMalehi ASKhan MTaher OMEASali SRizvi MDolatabadi AShreshtha NEkadashi RKumar ABasit ZfalseMapping antimicrobial susceptibility of community-acquired uropathogenic Escherichia coli across low, middle and high-income countries highlights significant differences: insights for empiric treatment.<h4>Objectives</h4>Rising antimicrobial resistance (AMR) in <i>Escherichia coli</i> urinary tract infections (UTI) poses a global challenge. Evidence-based treatment of cystitis requires local resistance data. The DASH to Protect Antibiotics (https://dashuti.com/), a multi-regional group, supports centers in generating and sharing focused antibiograms to guide stewardship in community UTIs. This multi-country study aimed to describe antimicrobial susceptibility patterns of community-acquired <i>E. coli</i> isolates in low, middle, and high-income countries (LMICs and HICs).<h4>Methods</h4>The study was conducted in 37 representative centers across 13 countries in Asia (Middle East and Indian Subcontinent), Africa, Europe, and North America. A rigorous comparative analysis of the antimicrob2025-01-01T00:00:00Z2025 Sep2026-05-04T16:43:43.05Z2026-04-07T20:40:48.003ZS-EPMC123570494082264010.1016/j.ijregi.2025.100706