{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pritam S"],"funding":["Austrian Science Fund FWF","NIH HHS","NIGMS NIH HHS","National Science Foundation"],"pagination":["258"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12357481"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>In our current understanding of transposable element (TE) invasions, TEs move freely until they accidentally insert into a piRNA cluster, where they are silenced by the production of piRNA cognate to the TE. Under this model, one would expect that selection might favor TEs that avoid piRNA clusters. However, empirical observations show that some TEs, such as the P-element, insert into piRNA clusters preferentially. We were thus wondering if such a bias, by minimizing harm to the host, could facilitate the spread of TEs throughout a population.<h4>Results</h4>We performed extensive forward simulations of TE invasions with different insertion biases into piRNA clusters to determine if there was ever a situation in which the insertion bias was beneficial to the TE. We found"],"journal":["BMC biology"],"pubmed_title":["The impact of insertion bias into piRNA clusters on the invasion of transposable elements."],"pmcid":["PMC12357481"],"funding_grant_id":["P35093","R35 GM155272","MIRA R35GM155272-01","NSF-EPSCoR-2032756"],"pubmed_authors":["Kofler R","Signor S","Scarpa A","Pritam S"],"additional_accession":[]},"is_claimable":false,"name":"The impact of insertion bias into piRNA clusters on the invasion of transposable elements.","description":"<h4>Background</h4>In our current understanding of transposable element (TE) invasions, TEs move freely until they accidentally insert into a piRNA cluster, where they are silenced by the production of piRNA cognate to the TE. Under this model, one would expect that selection might favor TEs that avoid piRNA clusters. However, empirical observations show that some TEs, such as the P-element, insert into piRNA clusters preferentially. We were thus wondering if such a bias, by minimizing harm to the host, could facilitate the spread of TEs throughout a population.<h4>Results</h4>We performed extensive forward simulations of TE invasions with different insertion biases into piRNA clusters to determine if there was ever a situation in which the insertion bias was beneficial to the TE. We found","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-13T17:16:48.038Z","creation":"2026-04-07T13:34:29.27Z"},"accession":"S-EPMC12357481","cross_references":{"pubmed":["40817053"],"doi":["10.1186/s12915-025-02370-0"]}}