{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Chen J"],"pubmed_abstract":["<h4>Background</h4>Shenyuan Yiqi Huoxue Capsule (SYYQ) has clinical evidence to improve coronary microvascular dysfunction (CMD) by tonifying qi and removing blood stasis, but the underlying mechanism remains unclear.<h4>Objective</h4>This study aims to explore the mechanism by which SYYQ alleviates CMD through a combination of network analysis and both <i>in vivo</i> and <i>in vitro</i> experiments.<h4>Methods</h4>First, network pharmacology was employed to predict the mechanism of SYYQ on CMD. Building upon the findings of network pharmacology, we conducted <i>in vivo</i> experiment to verify the improvement mechanism of SYYQ in CMD rats using echocardiography, histopathology, serum biochemistry, TUNEL staining, and transmission electron microscopy (TEM). In the context of cell experimen"],"journal":["Frontiers in pharmacology"],"pagination":["1534967"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12358463"],"repository":["biostudies-literature"],"pubmed_title":["Mechanism of Shenyuan Yiqi Huoxue capsule alleviating coronary microvascular dysfunction: network analysis and experimental evidence."],"pmcid":["PMC12358463"],"pubmed_authors":["Liu H","Li X","Li Y","Chen J","Zong H","Zhang S","Zhou H","Shi Y"],"additional_accession":[]},"is_claimable":false,"name":"Mechanism of Shenyuan Yiqi Huoxue capsule alleviating coronary microvascular dysfunction: network analysis and experimental evidence.","description":"<h4>Background</h4>Shenyuan Yiqi Huoxue Capsule (SYYQ) has clinical evidence to improve coronary microvascular dysfunction (CMD) by tonifying qi and removing blood stasis, but the underlying mechanism remains unclear.<h4>Objective</h4>This study aims to explore the mechanism by which SYYQ alleviates CMD through a combination of network analysis and both <i>in vivo</i> and <i>in vitro</i> experiments.<h4>Methods</h4>First, network pharmacology was employed to predict the mechanism of SYYQ on CMD. Building upon the findings of network pharmacology, we conducted <i>in vivo</i> experiment to verify the improvement mechanism of SYYQ in CMD rats using echocardiography, histopathology, serum biochemistry, TUNEL staining, and transmission electron microscopy (TEM). In the context of cell experimen","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-01T01:42:44.152Z","creation":"2026-04-07T16:33:23.322Z"},"accession":"S-EPMC12358463","cross_references":{"pubmed":["40832612"],"doi":["10.3389/fphar.2025.1534967"]}}