{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stewart DC"],"funding":["NCRR NIH HHS","National Institutes of Health","NIAMS NIH HHS","Russian Science Foundation","Perelman School of Medicine, University of Pennsylvania","NIH HHS","NIGMS NIH HHS","National Science Foundation"],"pagination":["919-938.e14"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12359077"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["145(4)"],"pubmed_abstract":["Postnatal cutaneous wound healing is characterized by development of a collagen-rich scar lacking the architecture and functional integrity of unwounded tissue. Directing cell behaviors to efficiently heal wounds while minimizing scar formation remains a major wound management goal. In this study, we demonstrate type III collagen (COL3) as a critical regulator of re-epithelialization and scar formation during healing of COL3-enriched, regenerative (Acomys), scar-permissive (CD-1 Mus and wild-type Col3<sup>B6/B6</sup> mice) and COL3-deficient, scar-promoting (Col3<sup>F/F</sup>, a murine conditional knockdown model) cutaneous wound models. We define a scar-permissive fibrillar collagen architecture signature characterized by elongated and anisotropically aligned collagen fibers that is dose"],"journal":["The Journal of investigative dermatology"],"pubmed_title":["Type III Collagen Regulates Matrix Architecture and Mechanosensing during Wound Healing."],"pmcid":["PMC12359077"],"funding_grant_id":["S10OD021633","S10 RR027128","P30AR069589","R01 GM124091","R01GM124091","P30 AR069589","CMMI-1751898","S10 OD021633","S10RR027128"],"pubmed_authors":["Maden M","Liu Y","Ruthel G","Yen WK","Mauck RL","Han L","Wang C","Volk SW","Brisson BK","Gullberg D","Stewart DC"],"additional_accession":[]},"is_claimable":false,"name":"Type III Collagen Regulates Matrix Architecture and Mechanosensing during Wound Healing.","description":"Postnatal cutaneous wound healing is characterized by development of a collagen-rich scar lacking the architecture and functional integrity of unwounded tissue. Directing cell behaviors to efficiently heal wounds while minimizing scar formation remains a major wound management goal. In this study, we demonstrate type III collagen (COL3) as a critical regulator of re-epithelialization and scar formation during healing of COL3-enriched, regenerative (Acomys), scar-permissive (CD-1 Mus and wild-type Col3<sup>B6/B6</sup> mice) and COL3-deficient, scar-promoting (Col3<sup>F/F</sup>, a murine conditional knockdown model) cutaneous wound models. We define a scar-permissive fibrillar collagen architecture signature characterized by elongated and anisotropically aligned collagen fibers that is dose","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-05-29T10:30:23.799Z","creation":"2026-04-08T04:30:04.246Z"},"accession":"S-EPMC12359077","cross_references":{"pubmed":["39236902"],"doi":["10.1016/j.jid.2024.08.013"]}}