{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["86"],"submitter":["Esparza-Molto PB"],"pubmed_abstract":["Mitochondrial reactive oxygen species (mtROS) regulate cellular signaling pathways, but also cause oxidative stress when de-regulated during aging and pathological conditions such as neurodegenerative diseases. The dynamic redistribution of proteins between cellular compartments is a common mechanism to control their stability and biological activities. By targeting the BirA∗ biotin ligase to the outer mitochondrial membrane in HEK293 cells, we identified proteins whose labeling increased or decreased in response to treatment with menadione, consistent with a dynamic change in their mitochondrial localization in response to increased mtROS production. These proteins represent potential candidates for future studies of mitochondrial oxidative stress signaling. A subset of glycolytic enzymes"],"journal":["Redox biology"],"pagination":["103812"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12359183"],"repository":["biostudies-literature"],"pubmed_title":["ROS-dependent localization of glycolytic enzymes to mitochondria."],"pmcid":["PMC12359183"],"pubmed_authors":["Bozkurt S","Newman LE","Gage FH","Shadel GS","Esparza-Molto PB","Jones JR","Goswami AV","Guan D","Moyzis AG","Munch C","Rojas GR"],"additional_accession":[]},"is_claimable":false,"name":"ROS-dependent localization of glycolytic enzymes to mitochondria.","description":"Mitochondrial reactive oxygen species (mtROS) regulate cellular signaling pathways, but also cause oxidative stress when de-regulated during aging and pathological conditions such as neurodegenerative diseases. The dynamic redistribution of proteins between cellular compartments is a common mechanism to control their stability and biological activities. By targeting the BirA∗ biotin ligase to the outer mitochondrial membrane in HEK293 cells, we identified proteins whose labeling increased or decreased in response to treatment with menadione, consistent with a dynamic change in their mitochondrial localization in response to increased mtROS production. These proteins represent potential candidates for future studies of mitochondrial oxidative stress signaling. A subset of glycolytic enzymes","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-08T15:37:44.962Z","creation":"2026-04-08T05:07:08.454Z"},"accession":"S-EPMC12359183","cross_references":{"pubmed":["40803248"],"doi":["10.1016/j.redox.2025.103812"]}}